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Title: | Dissociation between CA3-CA1 synaptic plasticity and associative learning in TgNTRK3 transgenic mice |
Author: | Sahún, Ignasi Delgado García, José M. Amador Arjona, Alejandro Giralt Torroella, Albert Alberch i Vié, Jordi Dierssen, Mara Gruart i Massó, Agnès |
Keywords: | Neurones Neuroplasticitat Ratolins transgènics Neurons Neuroplasticity Transgenic mice |
Issue Date: | 28-Feb-2007 |
Publisher: | The Society for Neuroscience |
Abstract: | Neurotrophins and their cognate receptors might serve as feedback regulators for the efficacy of synaptic transmission.Weanalyzed mice</p><p>overexpressing TrkC (TgNTRK3) for synaptic plasticity and the expression of glutamate receptor subunits. Animals were conditioned</p><p>using a trace [conditioned stimulus (CS), tone; unconditioned stimulus (US), shock] paradigm. A single electrical pulse presented to the</p><p>Schaffer collateral– commissural pathway during the CS–US interval evoked a monosynaptic field EPSP (fEPSP) at ipsilateral CA1</p><p>pyramidal cells. In wild types, fEPSP slopes increased across conditioning sessions and decreased during extinction, being linearly</p><p>related to learning evolution. In contrast, fEPSPs in TgNTRK3 animals reached extremely high values, not accompanied with a proportionate</p><p>increase in their learning curves. Long-term potentiation evoked in conscious TgNTRK3 was also significantly longer lasting than</p><p>in wild-type mice. These functional alterations were accompanied by significant changes inNR1andNR2BNMDAreceptor subunits, with</p><p>no modification of NR1Ser 896 or NR1Ser 897 phosphorylation. No changes of AMPA and kainate subunits were detected. Results indicate</p><p>that the NT-3/TrkC cascade could regulate synaptic transmission and plasticity through modulation of glutamatergic transmission at the</p><p>CA3–CA1 synapse. |
Note: | Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.4055-06.2007 |
It is part of: | Journal of Neuroscience, 2007, num.9, p. 2253-2260 |
URI: | http://hdl.handle.net/2445/207666 |
Related resource: | https://doi.org/10.1523/JNEUROSCI.4055-06.2007 |
ISSN: | 0270-6474 |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Articles publicats en revistes (Biomedicina) |
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