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http://hdl.handle.net/2445/207668| Title: | RTP801/REDD1 contributes to neuroinflammation severity and memory impairments in Alzheimer's disease |
| Author: | Pérez Sisqués, Leticia Sancho Balsells, Anna Solana Balaguer, Júlia Campoy Campos, Genís Vives Isern, Marcel Soler Palazón, Ferran Anglada Huguet, Marta López Toledano, Miguel Ángel Mandelkow, Eva Maria Alberch i Vié, Jordi Giralt Torroella, Albert Malagelada Grau, Cristina |
| Keywords: | Cervell Mort cel·lular Malaltia d'Alzheimer Malalties cerebrals Proteïnes Brain Cell death Alzheimer's disease Brain diseases Proteins |
| Issue Date: | 15-Jun-2021 |
| Publisher: | Nature Publishing Group |
| Abstract: | We found an unanticipated recovery of several gliosis hallmarks and inflammasome key proteins upon neuronal RTP801 downregulation in the 5xFAD mice. Altogether our results suggest that RTP801 could be a potential future target for theranostic studies since it could be a biomarker of neuroinflammation and neurotoxicity severity of the disease and, at the same time, a promising therapeutic target in the treatment of AD. |
| Note: | Reproducció del document publicat a: |
| It is part of: | Cell Death and Disease, 2021, vol. 12, num.6 |
| URI: | http://hdl.handle.net/2445/207668 |
| ISSN: | 2041-4889 |
| Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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|---|---|---|---|---|
| 240384.pdf | 5 MB | Adobe PDF | View/Open |
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