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http://hdl.handle.net/2445/208466
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DC Field | Value | Language |
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dc.contributor.author | Navarro Compán, Victoria | - |
dc.contributor.author | Puig, Luis | - |
dc.contributor.author | Vidal, Silvia | - |
dc.contributor.author | Ramírez, Julio | - |
dc.contributor.author | Llamas Velasco, Mar | - |
dc.contributor.author | Fernández Carballido, Cristina | - |
dc.contributor.author | Almodóvar, Raquel | - |
dc.contributor.author | Pinto, José Antonio | - |
dc.contributor.author | Galíndez Aguirregoikoa, Eva | - |
dc.contributor.author | Zarco, Pedro | - |
dc.contributor.author | Joven, Beatriz | - |
dc.contributor.author | Gratacós, Jordi | - |
dc.contributor.author | Juanola, Xavier | - |
dc.contributor.author | Blanco, Ricardo | - |
dc.contributor.author | Arias Santiago, Salvador | - |
dc.contributor.author | Sanz Sanz, Jesús | - |
dc.contributor.author | Queiro, Rubén | - |
dc.contributor.author | Cañete, Juan D. | - |
dc.date.accessioned | 2024-03-06T15:14:13Z | - |
dc.date.available | 2024-03-06T15:14:13Z | - |
dc.date.issued | 2023-08-04 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/2445/208466 | - |
dc.description.abstract | Interleukin-17 family (IL-17s) comprises six structurally related members (IL-17A to IL-17F); sequence homology is highest between IL-17A and IL-17F, displaying certain overlapping functions. In general, IL-17A and IL-17F play important roles in chronic inflammation and autoimmunity, controlling bacterial and fungal infections, and signaling mainly through activation of the nuclear factor-kappa B (NF-kappa B) pathway. The role of IL-17A and IL-17F has been established in chronic immune-mediated inflammatory diseases (IMIDs), such as psoriasis (PsO), psoriatic arthritis (PsA), axial spondylarthritis (axSpA), hidradenitis suppurativa (HS), inflammatory bowel disease (IBD), multiple sclerosis (MS), and asthma. CD4(+) helper T cells (Th17) activated by IL-23 are well-studied sources of IL-17A and IL-17F. However, other cellular subtypes can also produce IL-17A and IL-17F, including gamma delta (gamma delta) T cells, alpha beta (alpha beta) T cells, type 3 innate lymphoid cells (ILC3), natural killer T cells (NKT), or mucosal associated invariant T cells (MAIT). Interestingly, the production of IL-17A and IL-17F by innate and innate-like lymphocytes can take place in an IL-23 independent manner in addition to IL-23 classical pathway. This would explain the limitations of the inhibition of IL-23 in the treatment of patients with certain rheumatic immune-mediated conditions such as axSpA. Despite their coincident functions, IL-17A and IL-17F contribute independently to chronic tissue inflammation having somehow non-redundant roles. Although IL-17A has been more widely studied, both IL-17A and IL-17F are overexpressed in PsO, PsA, axSpA and HS. Therefore, dual inhibition of IL-17A and IL-17F could provide better outcomes than IL-23 or IL-17A blockade. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media SA | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fimmu.2023.1191782 | - |
dc.relation.ispartof | Frontiers in Immunology, 2023, vol. 14 | - |
dc.relation.uri | https://doi.org/10.3389/fimmu.2023.1191782 | - |
dc.rights | cc by (c) Navarro Compán, Victoria et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Malalties cròniques | - |
dc.subject.classification | Limfòcits | - |
dc.subject.classification | Psoriasi | - |
dc.subject.other | Chronic Disease | - |
dc.subject.other | Lymphocytes | - |
dc.subject.other | Psoriasis | - |
dc.title | The paradigm of IL-23-independent production of IL-17F and IL-17A and their role in chronic inflammatory diseases | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-09-12T11:32:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37600764 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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File | Description | Size | Format | |
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fimmu-14-1191782.pdf | 4.26 MB | Adobe PDF | View/Open |
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