Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/209227
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Botta, Cirino | - |
dc.contributor.author | Pérez, Cristina | - |
dc.contributor.author | Larrayoz, Marta | - |
dc.contributor.author | Puig, Noemí | - |
dc.contributor.author | Cedena, María Teresa | - |
dc.contributor.author | Termini, Rosalinda | - |
dc.contributor.author | Goicoechea, Ibai | - |
dc.contributor.author | Rodríguez, Sara | - |
dc.contributor.author | Zabaleta, Aintzane | - |
dc.contributor.author | Lopez, Aitziber | - |
dc.contributor.author | Sarvide, Sarai | - |
dc.contributor.author | Blanco, Laura | - |
dc.contributor.author | Papetti, Daniele M. | - |
dc.contributor.author | Nobile, Marco S. | - |
dc.contributor.author | Besozzi, Daniela | - |
dc.contributor.author | Gentile, Massimo | - |
dc.contributor.author | Correale, Pierpaolo | - |
dc.contributor.author | Siragusa, Sergio | - |
dc.contributor.author | Oriol, Albert | - |
dc.contributor.author | González García, Maria Esther | - |
dc.contributor.author | Sureda, Anna | - |
dc.contributor.author | Arriba, Felipe de | - |
dc.contributor.author | Rios Tamayo, Rafael | - |
dc.contributor.author | Moraleda, José María | - |
dc.contributor.author | Gironella, Mercedes | - |
dc.contributor.author | Hernández, Miguel T. | - |
dc.contributor.author | Bargay, Joan | - |
dc.contributor.author | Palomera, Luís | - |
dc.contributor.author | Pérez Montaña, Albert | - |
dc.contributor.author | Goldschmidt, Hartmut | - |
dc.contributor.author | Avet Loiseau, Hervé | - |
dc.contributor.author | Roccaro, Aldo | - |
dc.contributor.author | Orfao, Alberto | - |
dc.contributor.author | Martínez López, Joaquín | - |
dc.contributor.author | Rosiñol, Laura | - |
dc.contributor.author | Lahuerta, Juan José | - |
dc.contributor.author | Blade, Joan | - |
dc.contributor.author | Mateos, María Victoria | - |
dc.contributor.author | San Miguel, Jesús F. | - |
dc.contributor.author | Martínez Climent, José Ángel | - |
dc.contributor.author | Paiva, Bruno | - |
dc.contributor.author | Programa Para El Estudio de la Terapéutica en Hemopatías Malignas/Grupo Español de Mieloma (PETHEMA/GEM) Cooperative Group | - |
dc.contributor.author | Immunocell Study Group | - |
dc.date.accessioned | 2024-03-27T08:59:08Z | - |
dc.date.available | 2024-03-27T08:59:08Z | - |
dc.date.issued | 2023-09-20 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2445/209227 | - |
dc.description.abstract | Tumor recognition by T cells is essential for antitumor immunity. A comprehensive characterization of T cell diversity may be key to understanding the success of immunomodulatory drugs and failure of PD-1 blockade in tumors such as multiple myeloma (MM). Here, we use single-cell RNA and T cell receptor sequencing to characterize bone marrow T cells from healthy adults (n = 4) and patients with precursor (n = 8) and full-blown MM (n = 10). Large T cell clones from patients with MM expressed multiple immune checkpoints, suggesting a potentially dysfunctional phenotype. Dual targeting of PD-1 + LAG3 or PD-1 + TIGIT partially restored their function in mice with MM. We identify phenotypic hallmarks of large intratumoral T cell clones, and demonstrate that the CD27- and CD27+ T cell ratio, measured by flow cytometry, may serve as a surrogate of clonal T cell expansions and an independent prognostic factor in 543 patients with MM treated with lenalidomide-based treatment combinations. Myelomagenesis progresses through well-defined pre-malignant states. Here, using single-cell RNA sequencing and T cell receptor repertoire analysis of bone marrow T cells in patients at different stages of myelomagenesis, the authors identify large clonotypic expansions characterized by the expression of multiple immune checkpoints. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Science and Business Media LLC | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1038/s41467-023-41562-6 | - |
dc.relation.ispartof | Nature Communications, 2023, vol. 14, num. 1 | - |
dc.relation.uri | https://doi.org/10.1038/s41467-023-41562-6 | - |
dc.rights | cc by (c) Botta, Cirino et al., 2023 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) | - |
dc.subject.classification | Mieloma múltiple | - |
dc.subject.classification | Resistència als medicaments | - |
dc.subject.other | Multiple Myeloma | - |
dc.subject.other | Drug resistance | - |
dc.title | Large T cell clones expressing immune checkpoints increase during multiple myeloma evolution and predict treatment resistance | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.date.updated | 2023-11-22T08:51:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 37730678 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
s41467-023-41562-6.pdf | 3.83 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License