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http://hdl.handle.net/2445/211540
Title: | Investigating bacterial infections in Galleria mellonella larvae: Insights into pathogen dissemination and behavior |
Author: | Admella, Joana Torrents Serra, Eduard |
Keywords: | Arnes Bacteris Dissecció Infeccions Moths Bacteria Dissection Infections |
Issue Date: | 1-Sep-2023 |
Publisher: | Elsevier |
Abstract: | The insect Galleria mellonella is an alternative animal model widely used for studying bacterial infections. It presents a wide range of advantages, including its low cost, easy maintenance and lack of ethical constraints. Among other features, their innate immune system is very similar to that of mammals. In this study, we dissected several larvae infected with important human pathogens: Mycobacterium abscessus, Staphylococcus aureus and Pseudomonas aeruginosa. By observing the fat body, gut, trachea, and hemolymph under the microscope, we were able to describe where bacteria tend to disseminate. We also quantified the number of bacteria in the hemolymph throughout the infection course and found significant differences between the different pathogens. With this work, we aimed to better understand the behavior and dissemination of bacteria in the infected larvae. |
Note: | Reproducció del document publicat a: https://doi.org/10.1016/j.jip.2023.107975 |
It is part of: | Journal of Invertebrate Pathology, 2023, vol. 200, p. 1-8 |
URI: | http://hdl.handle.net/2445/211540 |
Related resource: | https://doi.org/10.1016/j.jip.2023.107975 |
ISSN: | 0022-2011 |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC)) |
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844151.pdf | 9.02 MB | Adobe PDF | View/Open |
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