Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/21371
Title: Inhibitors of the M2 channel of influenza A virus
Author: Duque, María D.
Torres, Eva
Valverde, Elena
Barniol-Xicota, Marta
Guardiola, Salvador
Rey, Matias
Vázquez Cruz, Santiago
Keywords: Influenzavirus
Resistència als medicaments
Inhibidors enzimàtics
Influenza viruses
Drug resistance
Enzyme inhibitors
Issue Date: 2011
Publisher: Transworld Research Network
Abstract: Influenza is a highly contagious, major respiratory tract disease affecting millions of people each year. At present, two classes of antivirals are available: the neuraminidase inhibitors and the M2 proton channel blockers amantadine and rimantadine. However, rapid emergence of M2 blockers resistance makes imperative the development of new anti-influenza drugs. In the last few years several groups have synthesized and evaluated several analogs of amantadine. While several of them are active against wild-type M2 channel only a few are able to inhibit the mutant ion channels that lead to amantadine-resistance.
Note: Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32392
Note: Reproducció del capítol 2 del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=106
It is part of: Recent Advances in Pharmaceutical Sciences, 2011, Chapter 2, p. 35-64. Editor: Diego Muñoz-Torrero
Related resource: http://hdl.handle.net/2445/32392
URI: http://hdl.handle.net/2445/21371
Appears in Collections:Llibres / Capítols de llibre (Farmacologia, Toxicologia i Química Terapèutica)

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