Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/22424
Title: Hepatitis C virus infection in 'primary' Sjögren's syndrome: prevalence and clinical significance in a series of 90 patients
Author: García Carrasco, Mario
Ramos Casals, Manuel
Cervera i Segura, Ricard, 1960-
Font Franco, Josep, 1953-2006
Vidal Cortada, Josep
Muñoz, Francisco J.
Miret Mas, Carlos
Espinosa Garriga, Gerard
Ingelmo Morín, Miguel
Keywords: Hepatitis C
Síndrome de Sjögren
Fetge
Epidemiologia
Hepatitis C
Sjögren's syndrome
Liver
Epidemiology
Issue Date: 1997
Publisher: BMJ Group
Abstract: OBJECTIVES—To determine the prevalence and clinical significance of hepatitis C virus (HCV) infection in a large cohort of patients with `primary' Sjögren's syndrome (SS).
METHODS—90 consecutive patients (83 female and seven male) were included, with a mean age of 62 years (range 31-80) who prospectively visited our unit. All patients fulfilled the European Community criteria for SS and underwent a complete history, physical examination, as well as biochemical and immunological evaluation for liver disease. Serum from all patients was tested for antibodies to HCV by third generation enzyme linked immunoassay and positivity was confirmed by polymerase chain reaction.
RESULTS—Antibodies to HCV were present in 13 (14%) patients with `primary' SS. When compared with patients without HCV infection, patients with HCV infection presented a higher prevalence of hepatic involvement (100% v 8%, p < 0.05). Transcutaneous liver biopsy was performed in five patients with HCV infection, and specimens obtained showed in all cases a chronic active hepatitis with varying degrees of portal inflammation.
CONCLUSION—HCV infection is frequent in patients with `primary' SS and liver involvement is present in all these patients. The possible pathogenic role of HCV infection in these patients is still unclear.


Note: Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.56.3.173
It is part of: Annals of the Rheumatic Diseases, 1997, vol. 56, núm. 3, p. 173-175
Related resource: http://dx.doi.org/10.1136/ard.56.3.173
URI: http://hdl.handle.net/2445/22424
ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)

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