Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/22441
Title: Systemic lupus erythematosus (SLE) in childhood: analysis of clinical and immunological findings in 34 patients and comparison with SLE characteristics in adults.
Author: Font Franco, Josep, 1953-2006
Cervera i Segura, Ricard, 1960-
Espinosa Garriga, Gerard
Pallarés Ferreres, Lucio
Ramos Casals, Manuel
Jiménez, Sonia
García Carrasco, Mario
Seisdedos, Luis
Ingelmo Morín, Miguel
Keywords: Lupus eritematós
Malalties dels infants
Adults
Immunologia
Lupus erythematosus
Children's diseases
Adulthood
Immunology
Issue Date: 1998
Publisher: BMJ Group
Abstract: OBJECTIVE—To define the pattern of disease expression in patients with childhood onset systemic lupus erythematosus (SLE).
METHODS—Prospective analysis of clinical manifestations and immunological features of 34 patients in whom the first manifestations appeared in childhood from a series of 430 unselected patients with SLE.
RESULTS—Thirty one (91%) patients from the childhood onset group were female and three male (9%) (ratio female/male, 10/1, with no difference compared with the adult onset group). Mean age of this group at disease onset was 11 years (range 5-14) compared with 32 years (15-48) for the remaining patients. The childhood onset patients more often had nephropathy (20% v 9% in adult onset SLE, p=0.04; OR:2.7; 95%CI:1.1, 7), fever (41% v 21%, p=0.006; OR:2.6, 95%CI:1.2, 5.7), and lymphadenopathy (6% v 0.5%, p=0.03, OR: 12.3, 95%CI: 1.2, 127.6), as presenting clinical manifestations. During the evolution of the disease, the childhood onset patients had an increased prevalence of malar rash (79% v 51%, p=0.002; OR:3.7; 95%CI:1.5, 9.5) and chorea (9% v 0%, p<0.0001). This group exhibited a higher prevalence of anticardiolipin antibodies (aCL) of the IgG isotype when compared with the remaining patients (29% v 13%, p=0.017; OR:2.9, 95%CI:1.2, 6.8). No significant differences were found among the other antibodies between the two groups. Childhood onset patients more often received azathioprine (15% v 6%, p=0.00004; OR:11.2; 95%CI:2.8, 44.9) but no differences were detected between the groups concerning side effects or drug toxicity.
CONCLUSIONS—The presentation and the clinical course of SLE varied in this series of 430 patients depending on their age at disease onset. Nephropathy, fever, and lymphadenopathy were more common in childhood onset patients as presenting clinical manifestations, while malar rash, chorea, and detection of IgG aCL were more common during the evolution of the disease.
Note: Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.57.8.456
It is part of: Annals of the Rheumatic Diseases, 1998, vol. 57, núm. 8, p. 456-459
URI: http://hdl.handle.net/2445/22441
Related resource: http://dx.doi.org/10.1136/ard.57.8.456
ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)

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