Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/22445
Title: Outcomes from studies of Antineutrophil Cytoplasm Antibody Associated Vasculitis: a systematic review by the European League Against Rheumatism systemic vasculitis task force.
Author: Mukhtyar, C.
Flossmann, O.
Hellmich, B.
Bacon, Paul A.
Cid Xutglà, M. Cinta
Cohen Tervaert, J. W.
Gross, W. L.
Guillevin, L.
Jayne, D. R.
Mahr, A.
Merkel, P. A.
Raspe, H.
Scott, D. G. I.
Witter, J.
Yazici, H.
Luqmani, R.
Keywords: Vasculitis
Autoanticossos
Vasculitis
Autoantibodies
Issue Date: 2007
Publisher: BMJ Group
Abstract: Objectives: We undertook a systematic literature review as a background to the European League Against Rheumatism (EULAR) recommendations for conducting clinical trials in anti-neutrophil cytoplasm antibody associated vasculitis (AAV), and to assess the quality of evidence for outcome measures in AAV. Methods: Using a systematic Medline search, we categorised the identified studies according to diagnoses. Factors affecting remission, relapse, renal function and overall survival were identified. Results: A total of 44 papers were reviewed from 502 identified by our search criteria. There was considerable inconsistency in definitions of end points. Remission rates varied from 30% to 93% in Wegener granulomatosis (WG), 75% to 89% in microscopic polyangiitis (MPA) and 81% to 91% in Churg¿Strauss syndrome (CSS). The 5-year survival for WG, MPA and CSS was 74¿91%, 45¿76% and 60¿97%. Relapse (variably defined) was common in the first 2 years but the frequency varied: 18% to 60% in WG, 8% in MPA, and 35% in CSS. The rate of renal survival in WG varied from 23% at 15 months to 23% at 120 months. Methods used to assess morbidity varied between studies. Ignoring the variations in definitions of the stage of disease, factors influencing remission, relapse, renal and overall survival included immunosuppressive therapy used, type of organ involvement, presence of ANCA, older age and male ender. Conclusions: Factors influencing remission, relapse, renal and overall survival include the type of immunosuppressive therapy used, pattern of organ involvement, presence of ANCA, older age and male gender. Methodological variations between studies highlight the need for a consensus on terminology and definitions for future conduct of clinical studies in AAV.
Note: Reproducció digital del document publicat a: http://dx.doi.org/10.1136/ard.2007.071936
It is part of: Annals of the Rheumatic Diseases, 2008, vol. 67, núm. 7, p. 1004-1010
Related resource: http://dx.doi.org/10.1136/ard.2007.071936
URI: http://hdl.handle.net/2445/22445
ISSN: 0003-4967
Appears in Collections:Articles publicats en revistes (Medicina)

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