Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/22489
Title: Effects of dietary fibre intake on risk factors for cardiovascular disease in subjects at high risk.
Author: Estruch Riba, Ramon
Martínez-González, Miguel Ángel, 1957-
Corella Piquer, Dolores
Basora-Gallisá, Josep
Ruiz-Gutiérrez, Valentina
Covas Planells, María Isabel
Fiol Sala, Miguel
Gómez Gracia, Enrique
López Sabater, María del Carmen
Escoda, R.
Pena, M. A.
Díez Espino, Javier
Lahoz, Carlos
Lapetra, José
Sáez, G.
Ros Rahola, Emilio
Keywords: Malalties cardiovasculars
Epidemiologia
Fibra alimentària
Estudi de casos
Cardiovascular diseases
Epidemiology
Dietary fiber
Case studies
Issue Date: 2009
Publisher: BMJ Group
Abstract: Background: Epidemiological studies and feeding trials with supplements suggest that fibre intake is associated with a reduction in cardiovascular risk. However, the effects of changes in dietary fibre on risk factor levels have not been evaluated in free-living individuals. Thus, we assessed the 3-month effects of changes in dietary fibre intake on cardiovascular risk factors in free-living high-risk subjects. Methods: 772 high-risk subjects (age 69?5 years) were assigned to a low-fat diet or 2 Mediterranean-style diets. All participants received behavioural and nutritional education, including recommendations for increasing the consumption of vegetables, fruits, and legumes. Changes in food and nutrient intake, body weight, blood pressure, lipid profiles, glucose control, and inflammatory markers were evaluated. Results: Most participants increased consumption of vegetable products, but the increase in dietary fibre exhibited wide between-subject variability (6-65 g/day). Body weight, waist circumference, and mean systolic and diastolic blood pressure decreased across quintiles of fibre intake (P <0.005; all). Reductions in fasting glucose and total cholesterol levels, and increments in HDL cholesterol were highest among participants in the upper 20% of fibre intake (P=0.04 and 0.02, respectively). Plasma concentrations of C-reactive protein, but not those of inflammatory cytokines, decreased in parallel with increasing dietary fibre (P=0.04). Significant reductions in LDL cholesterol were observed only among participants with the greatest increases in soluble fibre intake (P=0.04). Conclusions: Increasing dietary fibre intake with natural foods is associated with reductions in classical and novel cardiovascular risk factors in a high risk cohort.
Note: Reproducció digital del document publicat a: http://dx.doi.org/10.1136/jech.2008.082214
It is part of: Journal of Epidemiology and Community Health, 2009, vol. 63, núm. 7, p. 582-588
Related resource: http://doi.org/10.1136/jech.2008.082214
URI: http://hdl.handle.net/2445/22489
ISSN: 0143-005X
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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