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|Title:||Calbindin D-28K and parvalbumin immunoreactivity in the frontal cortex in patients with frontal lobe dementia of non-Alzheimer type associated with amyotrophic lateral sclerosis|
|Author:||Ferrer, Isidro (Ferrer Abizanda)|
Serrano Piñol, M. Teresa
Alcántara Horrillo, Soledad
Zújar, M. J.
Rivera, R. M.
|Keywords:||Esclerosi lateral amiotròfica|
Amyotrophic lateral sclerosis
|Publisher:||BMJ Publishing Group|
|Abstract:||The morphology and distribution of local-circuit neurons (interneurons) were examined, by calbindin D-28k and parvalbumin immunocytochemistry, in the frontal cortex (area 8) in two patients with frontal lobe dementia of non-Alzheimer type associated with classical amyotrophic lateral sclerosis (ALS), and in seven normal cases. The density of calbindin D-28k immunoreactive cells was dramatically reduced in ALS patients, but the density of parvalbumin-immunoreactive neurons was preserved. Decreased density of calbindin D-28k-immunoreactive neurons, which are mainly located in the upper cortical layers, may interfere with the normal processing of cortico-cortical connections, whereas integrity of parvalbumin-immunoreactive cells may be associated with the preservation of the major inhibitory intracortical circuits in patients with frontal lobe dementia.|
|Note:||Reproducció del document publicat a: http://dx.doi.org/10.1136/jnnp.56.3.257|
|It is part of:||Journal of Neurology Neurosurgery and Psychiatry, 1993, num. 56, p. 257-261|
|Appears in Collections:||Articles publicats en revistes (Patologia i Terapèutica Experimental)|
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