Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/25804
Title: Thermal activation and ATP dependence of the cytoskeleton remodeling dynamics
Author: Farré Ventura, Ramon
Navajas Navarro, Daniel
Keywords: Citosquelet
Models biològics
Adenosina
Cytoskeleton
Biological models
Adenosine
Issue Date: 2009
Publisher: American Physical Society
Abstract: The cytoskeleton (CSK) is a nonequilibrium polymer network that uses hydrolyzable sources of free energy such as adenosine triphosphate (ATP) to remodel its internal structure. As in inert nonequilibrium soft materials, CSK remodeling has been associated with structural rearrangements driven by energy-activated processes. We carry out particle tracking and traction microscopy measurements of alveolar epithelial cells at various temperatures and ATP concentrations. We provide the first experimental evidence that the remodeling dynamics of the CSK is driven by structural rearrangements over free-energy barriers induced by thermally activated forces mediated by ATP. The measured activation energy of these forces is ~40kBTr (kB being the Boltzmann constant and Tr being the room temperature). Our experiments provide clues to understand the analogy between the dynamics of the living CSK and that of inert nonequilibrium soft materials.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1103/PhysRevE.79.051920
It is part of: Physical Review E, 2009, vol. 79, num 5, p. 51920/1-51920/7
Related resource: http://dx.doi.org/10.1103/PhysRevE.79.051920
URI: http://hdl.handle.net/2445/25804
ISSN: 1063-651X
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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