Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/27933
Title: Circadian-related heteromerization of adrenergic and dopamine D4 receptors modulates melatonin synthesis and release in the pineal gland
Author: González, Sergio
Moreno Delgado, David
Moreno Guillén, Estefanía
Pérez Capote, Kamil
Franco Fernández, Rafael
Mallol Montero, Josefa
Cortés Tejedor, Antonio
Casadó, Vicent
Lluís i Biset, Carme
Ortiz, Jordi
Ferré, Sergi
Canela Campos, Enric I.
McCormick, Peter J.
Keywords: Glàndula pineal
Melatonina
Receptors adrenèrgics
Adenosina
Pineal gland
Melatonin
Adrenaline receptors
Adenosine
Issue Date: 19-Jun-2012
Publisher: Public Library of Science (PLoS)
Abstract: The role of the pineal gland is to translate the rhythmic cycles of night and day encoded by the retina into hormonal signals that are transmitted to the rest of the neuronal system in the form of serotonin and melatonin synthesis and release. Here we describe that the production of both melatonin and serotonin by the pineal gland is regulated by a circadian-related heteromerization of adrenergic and dopamine D4 receptors. Through alpha18-D4 and ß1-D4 receptor heteromers dopamine inhibits adrenergic receptor signaling and blocks the synthesis of melatonin induced by adrenergic receptor ligands. This inhibition was not observed at hours of the day when D4 was not expressed. These data provide a new perspective on dopamine function and constitute the first example of a circadian-controlled receptor heteromer. The unanticipated heteromerization between adrenergic and dopamine D4 receptors provides a feedback mechanism for the neuronal hormone system in the form of dopamine to control circadian inputs.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pbio.1001347
It is part of: PLoS Biology, 2012, vol. 10, num. 6
Related resource: http://dx.doi.org/10.1371/journal.pbio.1001347
URI: http://hdl.handle.net/2445/27933
ISSN: 1544-9173
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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