Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/32242
Title: Immunomodulation by conjugated linoleic acid (CLA) in early life
Author: Pérez-Cano, Francisco J.
Ramírez Santana, Carolina
Castell, Margarida
Castellote i Bargalló, M. Cristina
Franch i Masferrer, Àngels
Keywords: Farmacologia
Sistema immunològic
Pharmacology
Immune system
Issue Date: 2012
Publisher: Transworld Research Network
Abstract: Conjugated linoleic acid (CLA) has been reported to exert beneficial physiological effects on body composition and the immune system. However, little information is available on the influence of CLA on immune function during early life periods. The present study evaluates the effect of feeding an 80:20 mixture of cis-9,trans-11- and trans-10,cis-12-CLA isomers during gestation, suckling and early infancy on the systemic and mucosal immune responses of Wistar rats at three different time points: at the end of the suckling period (21-day-old rats), in early infancy (28-day-old rats), and later in life (adulthood). Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the milk of CLA-fed dams and in the plasma of all CLA-supplemented pups, and the highest content was achieved in those rats supplemented over the longest period. Dietary supplementation with that CLA mix enhances the systemic production of the main in vivo and ex vivo immunoglobulin (Ig) isotypes in 21- and 28-day-old rats. Moreover, CLA supplementation during suckling and early infancy also enhances the humoral immune defenses at intestinal level, by means of mucosal IgA increase, whereas down-regulates the systemic lymphoproliferative response. Finally, we described herein how feeding a diet enriched with the same isomer mix of cis9,trans11- and trans10,cis12-CLA from gestation to adulthood improves the capacity of adult rats to achieve a specific systemic and mucosal immune responses. All these data support the immunomodulatory effects of dietary supplementation of CLA, particularly of the cis9,trans11-CLA isomer, during early stages of life on immune system development, as well as the long-term effects on the specific immune response in adult age.
Note: Podeu consultar el llibre complet a: http://hdl.handle.net/2445/32393
Note: Reproducció del capítol 12 del llibre publicat a: http://www.trnres.com/ebookcontents.php?id=131
It is part of: Recent Advances in Pharmaceutical Sciences II, 2012, Editor: Diego Muñoz-Torrero, Diego Haro and Joan Vallès, Chapter 12, p. 203-232.
Related resource: http://hdl.handle.net/2445/32393
URI: http://hdl.handle.net/2445/32242
Appears in Collections:Llibres / Capítols de llibre (Bioquímica i Fisiologia)

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