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Title: The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration
Author: Gentile, L.
Cebrià Sánchez, Francesc
Bartscherer, Kerstin
Keywords: Planària (Gènere)
Cèl·lules mare
Regeneració (Biologia)
Regeneració del sistema nerviós
Planaria (Genus)
Stem cells
Regeneration (Biology)
Nervous system regeneration
Issue Date: 1-Jan-2011
Publisher: The Company of Biologists
Abstract: Planarian flatworms are an exception among bilaterians in that they possess a large pool of adult stem cells that enables them to promptly regenerate any part of their body, including the brain. Although known for two centuries for their remarkable regenerative capabilities, planarians have only recently emerged as an attractive model for studying regeneration and stem cell biology. This revival is due in part to the availability of a sequenced genome and the development of new technologies, such as RNA interference and next-generation sequencing, which facilitate studies of planarian regeneration at the molecular level. Here, we highlight why planarians are an exciting tool in the study of regeneration and its underlying stem cell biology in vivo, and discuss the potential promises and current limitations of this model organism for stem cell research and regenerative medicine.
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It is part of: Disease Models & Mechanisms, 2011, vol. 4, p. 12-19
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ISSN: 1754-8403
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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