Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/34516
Title: Immunomodulatory effect of mesenchymal stem cells on B cells
Author: Franquesa, Marcella
Hoogduijn, M.J.
Bestard Matamoros, Oriol
Grinyo Boira, Josep M.
Keywords: Trasplantament d'òrgans
Immunosupressió
Transplantation of organs
Immunosuppression
Issue Date: 20-Jul-2012
Publisher: Frontiers Media
Abstract: The research on T cell immunosuppression therapies has attracted most of the attention in clinical transplantation. However, B cells and humoral immune responses are increasingly acknowledged as crucial mediators of chronic allograft rejection. Indeed, humoral immune responses can lead to renal allograft rejection even in patients whose cell-mediated immune responses are well controlled. On the other hand, newly studied B cell subsets with regulatory effects have been linked to tolerance achievement in transplantation. Better understanding of the regulatory and effector B cell responses may therefore lead to new therapeutic approaches. Mesenchymal stem cells (MSC) are arising as a potent therapeutic tool in transplantation due to their regenerative and immunomodulatory properties.The research on MSCs has mainly focused on their effects onT cells and although data regarding the modulatory effects of MSCs on alloantigen-specific humoral response in humans is scarce, it has been demonstrated that MSCs significantly affect B cell functioning. In the present review we will analyze and discuss the results in this field.
Note: Reproducció del document publicat a: http://dx.doi.org/10.3389/fimmu.2012.00212
It is part of: Frontiers in Immunology, 2012, vol. 3, p. 212
Related resource: http://dx.doi.org/10.3389/fimmu.2012.00212
URI: http://hdl.handle.net/2445/34516
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

Files in This Item:
File Description SizeFormat 
621675.pdf555.23 kBAdobe PDFView/Open


This item is licensed under a Creative Commons License Creative Commons