Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/34526
Title: Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model
Author: Kurdián, Melania
Herrero Fresneda, Immaculada
Lloberas Blanch, Núria
Giménez Bonafé, Pepita
Coria, Virginia
Grande, María T.
Boggia, José
Malacrida, Leonel
Torras Ambròs, Joan
Arévalo, Miguel A.
González-Martínez, Francisco
López-Novoa, José M.
Grinyo Boira, Josep M.
Noboa, Oscar
Keywords: Medicaments
Transplantament renal
Proteïnuria
Immunosupressió
Drugs
Kidney transplantation
Proteinuria
Immunosuppression
Issue Date: 12-Mar-2012
Publisher: Public Library of Science (PLoS)
Abstract: The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032516
It is part of: PLoS One, 2012, vol. 7, núm. 3, p. e32516
Related resource: http://dx.doi.org/10.1371/journal.pone.0032516
URI: http://hdl.handle.net/2445/34526
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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