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Title: Delayed mTOR inhibition with low dose of everolimus reduces TGFβ expression, attenuates proteinuria and renal damage in the renal mass reduction model
Author: Kurdián, Melania
Herrero Fresneda, Immaculada
Lloberas Blanch, Núria
Giménez Bonafé, Pepita
Coria, Virginia
Grande, María T.
Boggia, José
Malacrida, Leonel
Torras Ambròs, Joan
Arévalo, Miguel A.
González-Martínez, Francisco
López-Novoa, José M.
Grinyó Boira, Josep M.
Noboa, Oscar
Keywords: Medicaments
Transplantament renal
Kidney transplantation
Issue Date: 12-Mar-2012
Publisher: Public Library of Science (PLoS)
Abstract: The immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating cell growth, proliferation, differentiation, migration, and survival. The aim of this study was to analyze the effects of delayed inhibition of mTOR pathway with low dose of everolimus on progression of renal disease and TGFβ expression in the 5/6 nephrectomy model in Wistar rats.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, núm. 3, p. e32516
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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