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Title: An enantioselective entry to cis-perhydroisoquinolines
Author: Amat Tusón, Mercedes
Pérez Bosch, Maria
Minaglia, Annamaria Tania
Casamitjana i Badia, Núria
Bosch Cartes, Joan
Keywords: Isoquinolina
Issue Date: 25-Jul-2005
Publisher: American Chemical Society
Abstract: An enantioselective route to cis-perhydroisoquinolines, involving a cyclocondensation reaction of (R)-phenylglycinol with a racemic oxoester, a stereoselective conjugate addition to an unsaturated bicyclic lactam, and the closure of the carbocyclic ring by a ring-closing metathesis as the key steps is reported. This route allows the preparation of 3-cyano derivatives as well as cis-octahydroisoquinolines bearing a quaternary center at the C4-position.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2005, vol. 7, num. 17, p. 3653-3656
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

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