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Title: Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
Author: Micó, Juan Antonio
Rojas Corrales, Maria Olga
Gibert Rahola, Juan
Parellada, Mara
Moreno, Dolores
Fraguas, David
Graell, Monterrat
Gil, Javier
Irazusta, Jon
Castro Fornieles, Josefina
Soutullo, Cesar
Arango, Celso
Otero, Soraya
Navarro, Ana
Baeza, Inmaculada
Martínez Cengotitabengoa, Mónica
González-Pinto, Ana
Keywords: Psicosi
Estrès oxidatiu
Oxidative stress
Issue Date: 14-Feb-2011
Publisher: BioMed Central
Abstract: Background:Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group. Methods: Total antioxidant status (TAS) and lipid peroxidation (LOOH) were determined in plasma. Enzyme activities and total glutathione levels were determined in erythrocytes in 102 children and adolescents with a first psychotic episode and 98 healthy controls. Results: A decrease in antioxidant defense was found in patients, measured as decreased TAS and glutathione levels. Lipid damage (LOOH) and glutathione peroxidase activity was higher in patients than controls. Our study shows a decrease in the antioxidant defense system in early onset first episode psychotic patients. Conclusions: Glutathione deficit seems to be implicated in psychosis, and may be an important indirect biomarker of oxidative stress in early-onset schizophrenia. Oxidative damage is present in these patients, and may contribute to its pathophysiology.
Note: Reproducció del document publicat a:
It is part of: BMC Psychiatry, 2011, vol. 11, p. 26
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ISSN: 1471-244X
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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