Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/35828
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dc.contributor.advisorGratacós Solsona, Eduard-
dc.contributor.advisorCrispi Brillas, Fàtima-
dc.contributor.authorComas Rovira, Montserrat-
dc.contributor.otherUniversitat de Barcelona. Departament d'Obstetrícia i Ginecologia, Pediatria i Radiologia i Medicina Física-
dc.date.accessioned2013-04-24T10:58:03Z-
dc.date.available2013-04-24T10:58:03Z-
dc.date.issued2011-05-16-
dc.identifier.urihttp://hdl.handle.net/2445/35828-
dc.description.abstract[eng] SUMMARY 1) Background Fetal growth restriction (FGR) is present in 5-10% of the pregnancies and is associated to high perinatal and long-term cardiovascular morbidity. Subclinical cardiac dysfunction has previously been described in severe and early FGR cases, but not in milder forms of late-FGR. The main aim of this thesis was to assess cardiac function by new echocardiographic techniques on myocardial imaging as Tissue Doppler Imaging (TDI), in early- and late-onset FGR cases. 2) Methods First, tissue Doppler was applied in a cohort of normally growth fetuses by TDI in order to describe its reproducibility and construct reference ranges for fetal annular peak velocities and myocardial performance index at 24-41 weeks of gestation. Secondly, cardiac function including conventional echocardiographic parameters and TDI was evaluated in a cohort of early-onset growth restricted fetuses with abnormal umbilical artery (UA) Doppler and, finally, in a cohort of late-onset small for gestational age (SGA) fetuses with normal UA Doppler. 3) Results Fetal TDI measurements demonstrated a good reproducibility. GA and estimated fetal weight (EFW) adjusted reference ranges for tissue Doppler indices at 24-41 weeks of gestation were provided. TDI demonstrated the presence of both systolic and diastolic cardiac dysfunction in early-onset FGR fetuses. Late-onset FGR fetuses with normal UA were also associated with cardiac dysfunction detected by TDI. 4) Conclusions Early- and late-onset growth restricted fetuses are associated with cardiac dysfunction. Subclinical cardiac dysfunction could be present from early stages of fetal deterioration and could be detected using TDI.cat
dc.format.extent123 p.cat
dc.format.mimetypeapplication/pdf-
dc.language.isoengcat
dc.publisherUniversitat de Barcelona-
dc.rights(c) Comas Rovira, 2011-
dc.subject.classificationMalformacions del cor-
dc.subject.classificationMalalties del fetus-
dc.subject.otherFetus -- Diseases-
dc.subject.otherCongenital heart disease-
dc.titleCardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restrictioneng
dc.typeinfo:eu-repo/semantics/doctoralThesis-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.dlB. 40513-2011cat
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.tdxhttp://hdl.handle.net/10803/51517-
Appears in Collections:Tesis Doctorals - Departament - Obstetrícia i Ginecologia, Pediatria i Radiologia i Medicina Física

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