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http://hdl.handle.net/2445/35828
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DC Field | Value | Language |
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dc.contributor.advisor | Gratacós Solsona, Eduard | - |
dc.contributor.advisor | Crispi Brillas, Fàtima | - |
dc.contributor.author | Comas Rovira, Montserrat | - |
dc.contributor.other | Universitat de Barcelona. Departament d'Obstetrícia i Ginecologia, Pediatria i Radiologia i Medicina Física | - |
dc.date.accessioned | 2013-04-24T10:58:03Z | - |
dc.date.available | 2013-04-24T10:58:03Z | - |
dc.date.issued | 2011-05-16 | - |
dc.identifier.uri | http://hdl.handle.net/2445/35828 | - |
dc.description.abstract | [eng] SUMMARY 1) Background Fetal growth restriction (FGR) is present in 5-10% of the pregnancies and is associated to high perinatal and long-term cardiovascular morbidity. Subclinical cardiac dysfunction has previously been described in severe and early FGR cases, but not in milder forms of late-FGR. The main aim of this thesis was to assess cardiac function by new echocardiographic techniques on myocardial imaging as Tissue Doppler Imaging (TDI), in early- and late-onset FGR cases. 2) Methods First, tissue Doppler was applied in a cohort of normally growth fetuses by TDI in order to describe its reproducibility and construct reference ranges for fetal annular peak velocities and myocardial performance index at 24-41 weeks of gestation. Secondly, cardiac function including conventional echocardiographic parameters and TDI was evaluated in a cohort of early-onset growth restricted fetuses with abnormal umbilical artery (UA) Doppler and, finally, in a cohort of late-onset small for gestational age (SGA) fetuses with normal UA Doppler. 3) Results Fetal TDI measurements demonstrated a good reproducibility. GA and estimated fetal weight (EFW) adjusted reference ranges for tissue Doppler indices at 24-41 weeks of gestation were provided. TDI demonstrated the presence of both systolic and diastolic cardiac dysfunction in early-onset FGR fetuses. Late-onset FGR fetuses with normal UA were also associated with cardiac dysfunction detected by TDI. 4) Conclusions Early- and late-onset growth restricted fetuses are associated with cardiac dysfunction. Subclinical cardiac dysfunction could be present from early stages of fetal deterioration and could be detected using TDI. | cat |
dc.format.extent | 123 p. | cat |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | cat |
dc.publisher | Universitat de Barcelona | - |
dc.rights | (c) Comas Rovira, 2011 | - |
dc.source | Tesis Doctorals - Departament - Obstetrícia i Ginecologia, Pediatria i Radiologia i Medicina Física | - |
dc.subject.classification | Malformacions del cor | - |
dc.subject.classification | Malalties del fetus | - |
dc.subject.other | Fetus -- Diseases | - |
dc.subject.other | Congenital heart disease | - |
dc.title | Cardiac dysfunction by tissue doppler in earty-and late-onset fetal growth restriction | eng |
dc.type | info:eu-repo/semantics/doctoralThesis | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.dl | B. 40513-2011 | cat |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.tdx | http://hdl.handle.net/10803/51517 | - |
Appears in Collections: | Tesis Doctorals - Departament - Obstetrícia i Ginecologia, Pediatria i Radiologia i Medicina Física |
Files in This Item:
File | Description | Size | Format | |
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MCR_THESIS.pdf | 3.58 MB | Adobe PDF | View/Open |
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