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http://hdl.handle.net/2445/36363
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DC Field | Value | Language |
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dc.contributor.author | Seira Oriach, Oscar | - |
dc.contributor.author | Gavín Marín, Rosalina | - |
dc.contributor.author | Gil Fernández, Vanessa | - |
dc.contributor.author | Llorens Torres, Franc | - |
dc.contributor.author | Rangel Rincones, Alejandra Helena | - |
dc.contributor.author | Soriano García, Eduardo | - |
dc.contributor.author | Río Fernández, José Antonio del | - |
dc.date.accessioned | 2013-04-26T14:18:19Z | - |
dc.date.available | 2013-04-26T14:18:19Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0022-3042 | - |
dc.identifier.uri | http://hdl.handle.net/2445/36363 | - |
dc.description.abstract | Lesioned axons do not regenerate in the adult mammalian central nervous system, owing to the overexpression of inhibitory molecules such as myelin-derived proteins or chondroitin sulphate proteoglycans. In order to overcome axon inhibition, strategies based on extrinsic and intrinsic treatments have been developed. For myelin-associated inhibition, blockage with NEP1-40, receptor bodies or IN-1 antibodies has been used. In addition, endogenous blockage of cell signalling mechanisms induced by myelin-associated proteins is a potential tool for overcoming axon inhibitory signals. We examined the participation of glycogen synthase kinase 3 (GSK3) and ERK1/2 in axon regeneration failure in lesioned cortical neurons. We also investigated whether pharmacological blockage of GSK3 and ERK1/2 activities facilitates regeneration after myelin-directed inhibition in two models: i) cerebellar granule cells and ii) lesioned entorhino-hippocampal pathway in slice cultures, and whether the regenerative effects are mediated by Nogo Receptor 1 (NgR1). We demonstrate that, in contrast to ERK1/2 inhibition, the pharmacological treatment of GSK3 inhibition strongly facilitated regrowth of cerebellar granule neurons over myelin independently of NgR1. Lastly these regenerative effects were corroborated in the lesioned EHP in NgR1 -/- mutant mice. These results provide new findings for the development of new assays and strategies to enhance axon regeneration in injured cortical connections. | - |
dc.format.extent | 30 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley | - |
dc.relation.isformatof | Versió preprint del document publicat a: http://dx.doi.org/10.1111/j.1471-4159.2010.06726.x | - |
dc.relation.ispartof | Journal of Neurochemistry, 2010, vol. 113, num. 6, p. 1644-1658 | - |
dc.relation.uri | http://dx.doi.org/10.1111/j.1471-4159.2010.06726.x | - |
dc.rights | (c) International Society for Neurochemistry, 2010 | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Neurones | - |
dc.subject.classification | Neurobiologia | - |
dc.subject.classification | Regeneració del sistema nerviós | - |
dc.subject.other | Neurons | - |
dc.subject.other | Neurobiology | - |
dc.subject.other | Nervous system regeneration | - |
dc.title | Neurites regrowth of cortical neurons by GSK3b inhibition independently of Nogo Receptor 1 | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/submittedVersion | - |
dc.identifier.idgrec | 583282 | - |
dc.date.updated | 2013-04-26T14:18:19Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
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583282.pdf | 244.47 kB | Adobe PDF | View/Open |
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