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Title: Two-year follow-op of cognitive functions in Schizophrenia spectrum disorders of adolescent patients treated with electroconvulsive therapy
Author: Serna, Elena de la
Flamarique, Itziar
Castro Fornieles, Josefina
Pons, Alexandre
Puig, Olga
Andrés Perpiña, Susana
Lázaro García, Luisa
Garrido, Juan Miguel
Bernardo Arroyo, Miquel
Baeza, Inmaculada
Keywords: Esquizofrènia
Psicopatologia de l'adolescència
Adolescent psychopathology
Electric shock
Issue Date: Dec-2011
Publisher: Mary Ann Liebert, Inc.
Abstract: Objective: The aim of the current study was to investigate the long-term cognitive effects of electroconvulsive therapy (ECT) in a sample of adolescent patients in whom schizophrenia spectrum disorders were diagnosed. Methods: The sample was composed of nine adolescent subjects in whom schizophrenia or schizoaffective disorder was diagnosed according to DSM-IV-TR criteria on whom ECT was conducted (ECT group) and nine adolescent subjects matched by age, socioeconomic status, and diagnostic and Positive and Negative Syndrome Scale (PANSS) total score at baseline on whom ECT was not conducted (NECT group). Clinical and neuropsychological assessments were carried out at baseline before ECT treatment and at 2-year follow-up. Results: Significant differences were found between groups in the number of unsuccessful medication trials. No statistically significant differences were found between the ECT group and theNECT group in either severity as assessed by the PANSS, or in any cognitive variables at baseline.At follow-up, both groups showed significant improvement in clinical variables (subscales of positive, general, and total scores of PANSS and Clinical Global Impressions-Improvement). In the cognitive assessment at follow-up, significant improvement was found in both groups in the semantic category of verbal fluency task and digits forward. However, no significant differences were found between groups in any clinical or cognitive variable at follow-up. Repeated measures analysis found no significant interaction of time · group in any clinical or neuropsychological measures. Conclusions: The current study showed no significant differences in change over time in clinical or neuropsychological variables between the ECT group and the NECT group at 2-year follow-up. Thus, ECT did not show any negative influence on long-term neuropsychological variables in our sample.
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It is part of: Journal of Child and Adolescent Psychopharmacology, 2011, vol. 21, num. 6, p. 611-619
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ISSN: 1044-5463
Appears in Collections:Articles publicats en revistes (Psicologia Clínica i Psicobiologia)

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