Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/36427
Title: Developmental expression of the oligodendrocyte myelin glycoprotein in the mouse telencephalon
Author: Gil, V.
Bichler, Z.
Lee, J.K.
Seira Oriach, Oscar
Llorens, Franc
Bribián Arruego,Ana
Morales, R.
Claverol-Tinture, E.
Soriano García, Eduardo
Sumoy, Lauro
Zheng, B.
Río Fernández, José Antonio del
Keywords: Mielina
Experimentació animal
Neurones
Myelin sheath
Animal experimentation
Neurons
Issue Date: 2010
Publisher: Oxford University Press
Abstract: The oligodendrocyte myelin glycoprotein is a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes in the CNS. Attempts have been made to identify the functions of the myelin-associated inhibitory proteins (MAIPs) after axonal lesion or in neurodegeneration. However, the developmental roles of some of these proteins and their receptors remain elusive. Recent studies indicate that NgR1 and the recently discovered receptor PirB restrict cortical synaptic plasticity. However, the putative factors that trigger these effects are unknown. Since Nogo-A is mostly associated with the endoplasmic reticulum and MAG appears late during development, the putative participation of OMgp should be considered. Here we examine the pattern of development of OMgp immunoreactive elements during mouse telencephalic development. OMgp immunoreactivity in the developing cortex follows the establishment of the thalamo-cortical barrel-field. At cellular level, we located OMgp neuronal membranes in dendrites and axons as well as in brain synaptosome fractions and axon varicosities. Lastly, the analysis of the barrel-field in OMgp-deficient mice revealed that although thalamo-cortical connections were formed, their targeting in layer IV was altered and numerous axons ectopically invaded layer II-III. Our data support the idea that early-expressed MAIPs play an active role during development and point to OMgp participating in thalamo-cortical connections.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1093/cercor/bhp246
It is part of: Cerebral Cortex, 2010, vol. 20, num. 8, p. 1769-1779
Related resource: http://dx.doi.org/10.1093/cercor/bhp246
URI: http://hdl.handle.net/2445/36427
ISSN: 1047-3211
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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