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http://hdl.handle.net/2445/36438
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DC Field | Value | Language |
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dc.contributor.author | Nocentini, Sara | - |
dc.contributor.author | Reginensi Espinoza, Diego | - |
dc.contributor.author | Garcia, Simon | - |
dc.contributor.author | Carulla Martí, Patricia | - |
dc.contributor.author | Moreno-Flores, María Teresa | - |
dc.contributor.author | Wandosell, Francisco | - |
dc.contributor.author | Trepat Guixer, Xavier | - |
dc.contributor.author | Bribián Arruego, Ana | - |
dc.contributor.author | Río Fernández, José Antonio del | - |
dc.date.accessioned | 2013-04-30T14:46:20Z | - |
dc.date.available | 2013-04-30T14:46:20Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1420-682X | - |
dc.identifier.uri | http://hdl.handle.net/2445/36438 | - |
dc.description.abstract | Newly generated olfactory receptor axons grow from the peripheral to the central nervous system aided by olfactory ensheathing cells (OECs). Thus, OEC transplantation has emerged as a promising therapy for spinal cord injuries and for other neural diseases. However, these cells do not present a uniform population, but, instead, a functionally heterogeneous population that exhibits a variety of responses including adhesion, repulsion and crossover during cell-cell and cell-matrix interactions. Some studies report that the migratory properties of OECs are compromised by inhibitory molecules and potentiated by chemical gradients. Here, we demonstrated that rodent OECs express all the components of the Nogo Receptor complex and that their migration is blocked by Myelin. Next, we used cell tracking and traction force microscopy to analyze OEC migration and its mechanical properties over Myelin. Our data relate the absence of traction force of OEC with lower migratory capacity, which correlates with changes in the F-Actin cytoskeleton and focal adhesion distribution. Lastly, OEC traction force and migratory capacity is enhanced after cell incubation with the Nogo Receptor inhibitor NEP1-40. | - |
dc.format.extent | 21 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Verlag | - |
dc.relation.isformatof | Versió postprint del document publicat a: http://dx.doi.org/10.1007/s00018-011-0893-1 | - |
dc.relation.ispartof | Cellular and Molecular Life Sciences, 2012, vol. 69, num. 10, p. 1689-1703 | - |
dc.relation.uri | http://dx.doi.org/10.1007/s00018-011-0893-1 | - |
dc.rights | (c) Springer Verlag, 2012 | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Mielina | - |
dc.subject.classification | Receptors cel·lulars | - |
dc.subject.classification | Neurobiologia | - |
dc.subject.other | Myelin sheath | - |
dc.subject.other | Cell receptors | - |
dc.subject.other | Neurobiology | - |
dc.title | Myelin-associated proteins block the migration of olfactory ensheathing cells: an in vitro study using single cell tracking and traction force microscopy | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 612828 | - |
dc.date.updated | 2013-04-30T14:46:20Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/FP7/242993/EU//GENESFORCEMOTION | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) Publicacions de projectes de recerca finançats per la UE |
Files in This Item:
File | Description | Size | Format | |
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612828.pdf | 310.18 kB | Adobe PDF | View/Open |
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