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Title: A systems biology approach identifies Molecular networks defining skeletal muscle abnormalities in chronic obstructive pulmonary disease.
Author: Turan, Nil
Kalko, Susana
Stincone, Anna
Clarke, Kim
Sabah, Ayesha
Howlett, Katherine
Curnow, S. John
Rodriguez, Diego A.
Cascante i Serratosa, Marta
O'Neill, Laura
Egginton, Stuart
Roca, Josep
Falciani, Francesco
Keywords: Malalties pulmonars obstructives cròniques
Sistemes biològics
Chronic obstructive pulmonary diseases
Biological systems
Issue Date: 2011
Publisher: Public Library of Science (PLoS)
Abstract: Chronic Obstructive Pulmonary Disease (COPD) is an inflammatory process of the lung inducing persistent airflow limitation. Extensive systemic effects, such as skeletal muscle dysfunction, often characterize these patients and severely limit life expectancy. Despite considerable research efforts, the molecular basis of muscle degeneration in COPD is still a matter of intense debate. In this study, we have applied a network biology approach to model the relationship between muscle molecular and physiological response to training and systemic inflammatory mediators. Our model shows that failure to co-ordinately activate expression of several tissue remodelling and bioenergetics pathways is a specific landmark of COPD diseased muscles. Our findings also suggest that this phenomenon may be linked to an abnormal expression of a number of histone modifiers, which we discovered correlate with oxygen utilization. These observations raised the interesting possibility that cell hypoxia may be a key factor driving skeletal muscle degeneration in COPD patients.
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It is part of: PLoS Computational Biology, 2011, vol. 7, num. 9, p. e1002129-e1002129
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ISSN: 1553-734X
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Medicina)

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