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DC Field | Value | Language |
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dc.contributor.author | Obiol Pardo, Cristian | - |
dc.contributor.author | Alcarráz Vizán, Gemma | - |
dc.contributor.author | Cascante i Serratosa, Marta | - |
dc.contributor.author | Rubio Martínez, Jaime | - |
dc.date.accessioned | 2013-05-06T15:29:08Z | - |
dc.date.available | 2013-05-06T15:29:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/42659 | - |
dc.description.abstract | Transketolase is an enzyme involved in a critical step of the non-oxidative branch of the pentose phosphate pathway whose inhibition could lead to new anticancer drugs. Here, we report new human transketolase inhibitors, based on the phenyl urea scaffold, found by applying structure-based virtual screening. These inhibitors are designed to cover a hot spot in the dimerization interface of the homodimer of the enzyme, providing for the first time compounds with a suggested novel binding mode not based on mimicking the thiamine pyrophosphate cofactor. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032276 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 3, p. e32276 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0032276 | - |
dc.rights | cc-by (c) Obiol Pardo, C. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Inhibidors enzimàtics | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Enzyme inhibitors | - |
dc.subject.other | Cancer | - |
dc.title | Diphenyl urea derivatives as inhibitors of transketolase: a structure-based virtual screening. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 615033 | - |
dc.date.updated | 2013-05-06T15:29:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22403640 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
Files in This Item:
File | Description | Size | Format | |
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615033.pdf | 392.7 kB | Adobe PDF | View/Open |
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