Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/43193
Title: Podocalyxin is a novel polysialylated neural adhesion protein with multiple roles in neural development and synapse formation
Author: Vitureira, N.
Andrés, R.
Perez Martinez, E.
Martínez García, Albert
Bribián Arruego,Ana
Blasi Cabús, Joan
Chelliah, S.
López Domenech, G.
Castro, F. de
Burgaya i Márquez, Ferran
McNagny, K.
Soriano García, Eduardo
Keywords: Neurobiologia del desenvolupament
Developmental neurobiology
Issue Date: 2010
Publisher: Public Library of Science (PLoS)
Abstract: Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show that PC is widely expressed in neurons during neural development. Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G. Experiments in vitro and phenotypic analyses of podxl-deficient mice indicate that PC is involved in neurite growth, branching and axonal fasciculation, and that PC loss-of-function reduces the number of synapses in the CNS and in the neuromuscular system. We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0012003
It is part of: PLoS One, 2010, vol. 5, num. 8, p. e12003
Related resource: http://dx.doi.org/10.1371/journal.pone.0012003
URI: http://hdl.handle.net/2445/43193
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Patologia i Terapèutica Experimental)

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