Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/43194
Title: Reelin controls progenitor cell migration in the healty and pathological adult brain
Author: Courtès, S.
Vernerey, J.
Pujadas Puigdomènech, Lluís
Magalon, K.
Cremer, H.
Soriano García, Eduardo
Durbec, P.
Cayre, M.
Keywords: Neurobiologia del desenvolupament
Hipocamp (Cervell)
Developmental neurobiology
Hippocampus (Brain)
Issue Date: 2011
Publisher: Public Library of Science (PLoS)
Abstract: Understanding the signals that control migration of neural progenitor cells in the adult brain may provide new therapeutic opportunities. Reelin is best known for its role in regulating cell migration during brain development, but we now demonstrate a novel function for reelin in the injured adult brain. First, we show that Reelin is upregulated around lesions. Second, experimentally increasing Reelin expression levels in healthy mouse brain leads to a change in the migratory behavior of subventricular zone-derived progenitors, triggering them to leave the rostral migratory stream (RMS) to which they are normally restricted during their migration to the olfactory bulb. Third, we reveal that Reelin increases endogenous progenitor cell dispersal in periventricular structures independently of any chemoattraction but via cell detachment and chemokinetic action, and thereby potentiates spontaneous cell recruitment to demyelination lesions in the corpus callosum. Conversely, animals lacking Reelin signaling exhibit reduced endogenous progenitor recruitment at the lesion site. Altogether, these results demonstrate that beyond its known role during brain development, Reelin is a key player in post-lesional cell migration in the adult brain. Finally our findings provide proof of concept that allowing progenitors to escape from the RMS is a potential therapeutic approach to promote myelin repair.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0020430
It is part of: PLoS One, 2011, vol. 6, num. 5, p. e20430
Related resource: http://dx.doi.org/10.1371/journal.pone.0020430
URI: http://hdl.handle.net/2445/43194
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)

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