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Title: Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta
Author: Liesa Torre-Marín, Montserrat
Borda d'Agua, Bárbara
Medina Gómez, Gema
Lelliott, Christopher J.
Paz, José Carlos
Rojo, Manuel
Palacín Prieto, Manuel
Vidal Puig, Antonio
Zorzano Olarte, Antonio
Keywords: Mitocondris
Regulació genètica
Genetic regulation
Issue Date: Oct-2008
Publisher: Public Library of Science (PLoS)
Abstract: Background There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. Methodology/Principal Findings Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1β is associated with a selective reduction in Mitofusin 2 (Mfn2) expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1β increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1β-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1β increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor α (ERRα). Conclusions/Significance Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1β in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2008, vol. 3, num. 10, p. e3613
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

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