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http://hdl.handle.net/2445/43201
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DC Field | Value | Language |
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dc.contributor.author | Liesa Torre-Marín, Montserrat | - |
dc.contributor.author | Borda d'Agua, Bárbara | - |
dc.contributor.author | Medina Gómez, Gema | - |
dc.contributor.author | Lelliott, Christopher J. | - |
dc.contributor.author | Paz, José Carlos | - |
dc.contributor.author | Rojo, Manuel | - |
dc.contributor.author | Palacín Prieto, Manuel | - |
dc.contributor.author | Vidal-Puig, Antonio | - |
dc.contributor.author | Zorzano Olarte, Antonio | - |
dc.date.accessioned | 2013-05-07T17:15:35Z | - |
dc.date.available | 2013-05-07T17:15:35Z | - |
dc.date.issued | 2008-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43201 | - |
dc.description.abstract | Background There is no evidence to date on whether transcriptional regulators are able to shift the balance between mitochondrial fusion and fission events through selective control of gene expression. Methodology/Principal Findings Here, we demonstrate that reduced mitochondrial size observed in knock-out mice for the transcriptional regulator PGC-1β is associated with a selective reduction in Mitofusin 2 (Mfn2) expression, a mitochondrial fusion protein. This decrease in Mfn2 is specific since expression of the remaining components of mitochondrial fusion and fission machinery were not affected. Furthermore, PGC-1β increases mitochondrial fusion and elongates mitochondrial tubules. This PGC-1β-induced elongation specifically requires Mfn2 as this process is absent in Mfn2-ablated cells. Finally, we show that PGC-1β increases Mfn2 promoter activity and transcription by coactivating the nuclear receptor Estrogen Related Receptor α (ERRα). Conclusions/Significance Taken together, our data reveal a novel mechanism by which mammalian cells control mitochondrial fusion. In addition, we describe a novel role of PGC-1β in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0003613 | - |
dc.relation.ispartof | PLoS One, 2008, vol. 3, num. 10, p. e3613 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0003613 | - |
dc.rights | cc-by (c) Liesa, M. et al., 2008 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Mitocondris | - |
dc.subject.classification | Regulació genètica | - |
dc.subject.other | Mitochondria | - |
dc.subject.other | Genetic regulation | - |
dc.title | Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 567847 | - |
dc.date.updated | 2013-05-07T17:15:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 18974884 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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567847.pdf | 473.88 kB | Adobe PDF | View/Open |
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