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Title: Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome
Author: Rodriguez-Frias, Francisco
Tabernero, David
Quer, Josep
Esteban, Juan I.
Ortega, Israel
Domingo, Esteban
Cubero, Maria
Camos, Sílvia
Ferrer Costa, Carles
Sànchez, Àlex (Sànchez Pla)
Jardí, Rosendo
Schaper, Melanie
Homs, Maria
García Cehic, Damir
Guardia, Jaume
Esteban, Rafael
Buti, Maria
Keywords: Hepatitis B
Medicaments antivírics
Expressió gènica
Hepatitis B
Antiviral agents
Gene expression
Issue Date: 30-May-2012
Publisher: Public Library of Science (PLoS)
Abstract: Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.
Note: Reproducció del document publicat a:
It is part of: PLoS One, 2012, vol. 7, num. 5, p. e37874
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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