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http://hdl.handle.net/2445/43202| Title: | Ultra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome |
| Author: | Rodríguez-Frías, Francisco Tabernero, David Quer, Josep Esteban, Juan I. Ortega, Israel Domingo, Esteban Cubero, Maria Camos, Sílvia Ferrer Costa, Carles Sànchez, Àlex (Sànchez Pla) Jardí, Rosendo Schaper, Melanie Homs, Maria García Cehic, Damir Guardia, Jaume Esteban, Rafael Buti, Maria |
| Keywords: | Hepatitis B Medicaments antivírics Expressió gènica Hepatitis B Antiviral agents Gene expression |
| Issue Date: | 30-May-2012 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | Selection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region. |
| Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0037874 |
| It is part of: | PLoS One, 2012, vol. 7, num. 5, p. e37874 |
| URI: | http://hdl.handle.net/2445/43202 |
| Related resource: | http://dx.doi.org/10.1371/journal.pone.0037874 |
| ISSN: | 1932-6203 |
| Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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