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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/43202
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dc.contributor.authorRodríguez-Frías, Francisco-
dc.contributor.authorTabernero, David-
dc.contributor.authorQuer, Josep-
dc.contributor.authorEsteban, Juan I.-
dc.contributor.authorOrtega, Israel-
dc.contributor.authorDomingo, Esteban-
dc.contributor.authorCubero, Maria-
dc.contributor.authorCamos, Sílvia-
dc.contributor.authorFerrer Costa, Carles-
dc.contributor.authorSànchez, Àlex (Sànchez Pla)-
dc.contributor.authorJardí, Rosendo-
dc.contributor.authorSchaper, Melanie-
dc.contributor.authorHoms, Maria-
dc.contributor.authorGarcía Cehic, Damir-
dc.contributor.authorGuardia, Jaume-
dc.contributor.authorEsteban, Rafael-
dc.contributor.authorButi, Maria-
dc.date.accessioned2013-05-07T17:43:09Z-
dc.date.available2013-05-07T17:43:09Z-
dc.date.issued2012-05-30-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/2445/43202-
dc.description.abstractSelection of amino acid substitutions associated with resistance to nucleos(t)ide-analog (NA) therapy in the hepatitis B virus (HBV) reverse transcriptase (RT) and their combination in a single viral genome complicates treatment of chronic HBV infection and may affect the overlapping surface coding region. In this study, the variability of an overlapping polymerase-surface region, critical for NA resistance, is investigated before treatment and under antiviral therapy, with assessment of NA-resistant amino acid changes simultaneously occurring in the same genome (linkage analysis) and their influence on the surface coding region.-
dc.format.extent15 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherPublic Library of Science (PLoS)-
dc.relation.isformatofReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0037874-
dc.relation.ispartofPLoS One, 2012, vol. 7, num. 5, p. e37874-
dc.relation.urihttp://dx.doi.org/10.1371/journal.pone.0037874-
dc.rightscc-by (c) Rodriguez Frías, F. et al., 2012-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Genètica, Microbiologia i Estadística)-
dc.subject.classificationHepatitis B-
dc.subject.classificationMedicaments antivírics-
dc.subject.classificationExpressió gènica-
dc.subject.otherHepatitis B-
dc.subject.otherAntiviral agents-
dc.subject.otherGene expression-
dc.titleUltra-Deep Pyrosequencing Detects Conserved Genomic Sites and Quantifies Linkage of Drug-Resistant Amino Acid Changes in the Hepatitis B Virus Genome-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec614276-
dc.date.updated2013-05-07T17:43:09Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid22666402-
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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