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http://hdl.handle.net/2445/43234| Title: | Large-scale evidence for the effect of the COL1A1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study |
| Author: | Ralston, Stuart H. Uitterlinden, André G. Brandi, Maria Luisa Balcells Comas, Susana Langdahl, Bente L. Lips, Paul Lorenc, Roman Obermayer-Pietsch, Barbara Scollen, Serena Bustamante Pineda, Mariona Bjerre Husted, Lise Carey, Alisoun H. Díez Pérez, Adolfo Dunning, Alison M. Falchetti, Alberto Karczmarewicz, Elzbieta Kruk, Marcin |
| Keywords: | Osteoporosi Genòmica Densitometria òssia Osteoporosis Genomics Bone densitometry |
| Issue Date: | Apr-2006 |
| Publisher: | Public Library of Science (PLoS) |
| Abstract: | Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-large-scale studies of COLIA1 alleles in relation to these phenotypes. |
| Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pmed.0030090 |
| It is part of: | PLoS Medicine, 2006, vol. 3, num. 4, p. 515-523 |
| URI: | http://hdl.handle.net/2445/43234 |
| Related resource: | http://dx.doi.org/10.1371/journal.pmed.0030090 |
| ISSN: | 1549-1277 |
| Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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