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Title: Large-scale evidence for the effect of the COL1A1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study
Author: Ralston, Stuart H.
Uitterlinden, André G.
Brandi, Maria Luisa
Balcells Comas, Susana
Langdahl, Bente L.
Lips, Paul
Lorenc, Roman
Obermayer-Pietsch, Barbara
Scollen, Serena
Bustamante Pineda, Mariona
Bjerre Husted, Lise
Carey, Alisoun H.
Diez Perez, Adolfo
Dunning, Alison M.
Falchetti, Alberto
Karczmarewicz, Elzbieta
Kruk, Marcin
Keywords: Osteoporosi
Densitometria òssia
Bone densitometry
Issue Date: Apr-2006
Publisher: Public Library of Science (PLoS)
Abstract: Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1 gene is a genetic marker for low bone mineral density (BMD) and osteoporotic fracture, but there have been no very-large-scale studies of COLIA1 alleles in relation to these phenotypes.
Note: Reproducció del document publicat a:
It is part of: PLoS Medicine, 2006, vol. 3, num. 4, p. 515-523
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ISSN: 1549-1277
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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