Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/43242
Title: Differential regulation of horizontally acquired and core genome genes by the bacterial modulator H-NS
Author: Baños Molina, Rosa Carmen
Vivero, A.
Aznar Vicente, S.
García, J.
Pons Vallès, Miquel
Madrid Xufré, Cristina
Juárez Giménez, Antonio
Keywords: Genòmica
Genètica bacteriana
ADN
Proteïnes
Genomics
Bacterial genetics
DNA
Proteins
Issue Date: Jun-2009
Publisher: Public Library of Science (PLoS)
Abstract: Horizontal acquisition of DNA by bacteria dramatically increases genetic diversity and hence successful bacterial colonization of several niches, including the human host. A relevant issue is how this newly acquired DNA interacts and integrates in the regulatory networks of the bacterial cell. The global modulator H-NS targets both core genome and HGT genes and silences gene expression in response to external stimuli such as osmolarity and temperature. Here we provide evidence that H-NS discriminates and differentially modulates core and HGT DNA. As an example of this, plasmid R27-encoded H-NS protein has evolved to selectively silence HGT genes and does not interfere with core genome regulation. In turn, differential regulation of both gene lineages by resident chromosomal H-NS requires a helper protein: the Hha protein. Tight silencing of HGT DNA is accomplished by H-NS-Hha complexes. In contrast, core genes are modulated by H-NS homoligomers. Remarkably, the presence of Hha-like proteins is restricted to the Enterobacteriaceae. In addition, conjugative plasmids encoding H-NS variants have hitherto been isolated only from members of the family. Thus, the H-NS system in enteric bacteria presents unique evolutionary features. The capacity to selectively discriminate between core and HGT DNA may help to maintain horizontally transmitted DNA in silent form and may give these bacteria a competitive advantage in adapting to new environments, including host colonization.
Note: Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pgen.1000513
It is part of: PLoS Genetics, 2009, vol. 5, num. 6 , p. e1000513
Related resource: http://dx.doi.org/10.1371/journal.pgen.1000513
URI: http://hdl.handle.net/2445/43242
ISSN: 1553-7390
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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