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Title: | Expression of Glycogen Phosphorylase Isoforms in Cultured Muscle from Patients with McArdle´s Disease Carrying the p.R771PfsX33 PYGM Mutation |
Author: | Nogales Gadea, Gisela Mormeneo, Emma Consuegra García, Inés Rubio, Juan C. Orozco, Anna Arenas, Joaquín Martín, Miguel A. Lucia, Alejandro Gómez Foix, Anna Maria Martí Seves, Ramon Andreu, Antoni |
Keywords: | Trastorns del metabolisme Genètica molecular Fisiologia patològica Glicogen Disorders of metabolism Molecular genetics Pathological physiology Glycogen |
Issue Date: | Oct-2010 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Mutations in the PYGM gene encoding skeletal muscle glycogen phosphorylase (GP) cause a metabolic disorder known as McArdle's disease. Previous studies in muscle biopsies and cultured muscle cells from McArdle patients have shown that PYGM mutations abolish GP activity in skeletal muscle, but that the enzyme activity reappears when muscle cells are in culture. The identification of the GP isoenzyme that accounts for this activity remains controversial. |
Note: | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0013164 |
It is part of: | PLoS One, 2010, vol. 5, num. 10, p. e13164 |
URI: | http://hdl.handle.net/2445/43264 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0013164 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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