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http://hdl.handle.net/2445/43320
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DC Field | Value | Language |
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dc.contributor.author | Blount, J. R. | - |
dc.contributor.author | Burr, A. A. | - |
dc.contributor.author | Denuc Isern, Amanda | - |
dc.contributor.author | Marfany i Nadal, Gemma | - |
dc.contributor.author | Todi, S. V. | - |
dc.date.accessioned | 2013-05-10T13:02:08Z | - |
dc.date.available | 2013-05-10T13:02:08Z | - |
dc.date.issued | 2012-05 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43320 | - |
dc.description.abstract | Endoplasmic Reticulum (ER)-associated degradation (ERAD) discards abnormal proteins synthesized in the ER. Through coordinated actions of ERAD components, misfolded/anomalous proteins are recognized, ubiquitinated, extracted from the ER and ultimately delivered to the proteasome for degradation. It is not well understood how ubiquitination of ERAD substrates is regulated. Here, we present evidence that the deubiquitinating enzyme Ubiquitin-Specific Protease 25 (USP25) is involved in ERAD. Our data support a model where USP25 counteracts ubiquitination of ERAD substrates by the ubiquitin ligase HRD1, rescuing them from degradation by the proteasome. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0036542 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 5, p. e36542 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0036542 | - |
dc.rights | cc-by (c) Blount, J.R. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Proteïnes | - |
dc.subject.classification | Enzims | - |
dc.subject.classification | Reticle endoplasmàtic | - |
dc.subject.other | Proteins | - |
dc.subject.other | Enzymes | - |
dc.subject.other | Endoplasmic reticulum | - |
dc.title | Ubiquitin-specific protease USP25 functions in endoplasmic reticulum-associated degradation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 614268 | - |
dc.date.updated | 2013-05-10T13:02:08Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22590560 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
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614268.pdf | 2.09 MB | Adobe PDF | View/Open |
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