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Title: Fragmentation of contaminant and endogenous DNA in ancient samples determined by shotgun sequencing; prospects for human palaeogenomics
Author: García Garcerà, M.
Gigli, E.
Sanchez Quinto, F.
Ramirez, O.
Calafell, Francesc
Civit Vives, Sergi
Lalueza Fox, Carles, 1965-
Keywords: ADN fòssil
Fossil DNA
Issue Date: 2011
Publisher: Public Library of Science (PLoS)
Abstract: Despite the successful retrieval of genomes from past remains, the prospects for human palaeogenomics remain unclear because of the difficulty of distinguishing contaminant from endogenous DNA sequences. Previous sequence data generated on high-throughput sequencing platforms indicate that fragmentation of ancient DNA sequences is a characteristic trait primarily arising due to depurination processes that create abasic sites leading to DNA breaks.
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It is part of: PLoS One, 2011, vol. 6, num. 8, p. e24161
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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