Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/43562
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sánchez Quinto, Federico | - |
dc.contributor.author | Rodríguez Botigué, Laura | - |
dc.contributor.author | Civit Vives, Sergi | - |
dc.contributor.author | Arenas Solà, Concepción | - |
dc.contributor.author | Ávila-Arcos, María C. | - |
dc.contributor.author | Bustamante, Carlos D. | - |
dc.contributor.author | Comas, David | - |
dc.contributor.author | Lalueza Fox, Carles, 1965- | - |
dc.date.accessioned | 2013-05-17T14:59:41Z | - |
dc.date.available | 2013-05-17T14:59:41Z | - |
dc.date.issued | 2012-10 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43562 | - |
dc.description.abstract | One of the main findings derived from the analysis of the Neandertal genome was the evidence for admixture between Neandertals and non-African modern humans. An alternative scenario is that the ancestral population of non-Africans was closer to Neandertals than to Africans because of ancient population substructure. Thus, the study of North African populations is crucial for testing both hypotheses. We analyzed a total of 780,000 SNPs in 125 individuals representing seven different North African locations and searched for their ancestral/derived state in comparison to different human populations and Neandertals. We found that North African populations have a significant excess of derived alleles shared with Neandertals, when compared to sub-Saharan Africans. This excess is similar to that found in non-African humans, a fact that can be interpreted as a sign of Neandertal admixture. Furthermore, the Neandertal's genetic signal is higher in populations with a local, pre-Neolithic North African ancestry. Therefore, the detected ancient admixture is not due to recent Near Eastern or European migrations. Sub-Saharan populations are the only ones not affected by the admixture event with Neandertals. | - |
dc.format.extent | 6 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0047765 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 10, p. e47765 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0047765 | - |
dc.rights | cc-by (c) Sánchez Quinto, F. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | ADN | - |
dc.subject.classification | Paleobiologia | - |
dc.subject.classification | Home de Neandertal | - |
dc.subject.classification | Àfrica del Nord | - |
dc.subject.classification | Paleobiologia evolutiva | - |
dc.subject.other | DNA | - |
dc.subject.other | Paleobiology | - |
dc.subject.other | Neanderthals | - |
dc.subject.other | Africa, North | - |
dc.subject.other | Evolutionary paleobiology | - |
dc.title | North African populations carry the signature of admixture with Neandertals | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 618206 | - |
dc.date.updated | 2013-05-17T14:59:42Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23082212 | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
618206.pdf | 581.13 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License