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Title: Factors Associated to Duration of Hepatitis A Outbreaks: Implications for Control
Author: Torner Gràcia, Núria
Broner, Sonia Judith
Martinez, Ana
Tortajada, Cecilia
García de Olalla, Patricia
Barrabeig i Fabregat, Irene
Sala, Maria Rosa
Camps, Neus
Minguell, Sofia
Alvarez, Josep
Ferrús, Gloria
Torra, Roser
Godoy i García, Pere
Domínguez García, Àngela
Hepatitis A Surveillance Group of Catalonia
Keywords: Virus de l'hepatitis A
Hepatitis A virus
Issue Date: 15-Feb-2012
Publisher: Public Library of Science (PLoS)
Abstract: Even though hepatitis A mass vaccination effectiveness is high, outbreaks continue to occur. The aim of this study was to investigate the association between duration and characteristics of hepatitis A outbreaks. Hepatitis A (HA) outbreaks reported between 1991 and 2007 were studied. An outbreak was defined as ≥2 epidemiologically-linked cases with ≥1 case laboratory-confirmed by detection of HA immunoglobulin M (IgM) antibodies. Relationships between explanatory variables and outbreak duration were assessed by logistic regression. During the study period, 268 outbreaks (rate 2.45 per million persons-year) and 1396 cases (rate 1.28 per 105 persons-year) were reported. Factors associated with shorter duration were time to intervention (OR = 0.96; 95% CI: 0.94-0.98) and school setting (OR = 0.39; 95% CI: 0.16-0.92). In person-to-person transmission outbreaks only time to intervention was associated with shorter outbreak duration (OR = 0.96; 95% CI: 0.95-0.98). The only variables associated with shorter outbreak duration were early administration of IG or vaccine and a school setting. Timely reporting HA outbreaks was associated with outbreak duration. Making confirmed HA infections statutory reportable for clinical laboratories could diminish outbreak duration.
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It is part of: PLoS One, 2012, vol. 7, num. 2, p. e31339
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ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Medicina)

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