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http://hdl.handle.net/2445/43658
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DC Field | Value | Language |
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dc.contributor.author | Pasarín Castellanos, Marcos | - |
dc.contributor.author | La Mura, Vincenzo | - |
dc.contributor.author | Gracia-Sancho, Jorge | - |
dc.contributor.author | García Calderó, Héctor | - |
dc.contributor.author | Rodríguez Vilarrupla, Aina | - |
dc.contributor.author | García Pagán, Juan Carlos | - |
dc.contributor.author | Bosch i Genover, Jaume | - |
dc.contributor.author | González-Abraldes Iglesias, Juan | - |
dc.date.accessioned | 2013-05-22T08:28:56Z | - |
dc.date.available | 2013-05-22T08:28:56Z | - |
dc.date.issued | 2012-04-03 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43658 | - |
dc.description.abstract | Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Most morbidity associated with the metabolic syndrome is related to vascular complications, in which endothelial dysfunction is a major pathogenic factor. However, whether NAFLD is associated with endothelial dysfunction within the hepatic vasculature is unknown. The aims of this study were to explore, in a model of diet-induced overweight that expresses most features of the metabolic syndrome, whether early NAFLD is associated with liver endothelial dysfunction. Wistar Kyoto rats were fed a cafeteria diet (CafD; 65% of fat, mostly saturated) or a control diet (CD) for 1 month. CafD rats developed features of the metabolic syndrome (overweight, arterial hypertension, hypertryglyceridemia, hyperglucemia and insulin resistance) and liver steatosis without inflammation or fibrosis. CafD rats had a significantly higher in vivo hepatic vascular resistance than CD. In liver perfusion livers from CafD rats had an increased portal perfusion pressure and decreased endothelium-dependent vasodilation. This was associated with a decreased Akt-dependent eNOS phosphorylation and NOS activity. In summary, we demonstrate in a rat model of the metabolic syndrome that shows features of NAFLD, that liver endothelial dysfunction occurs before the development of fibrosis or inflammation. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0032785 | - |
dc.relation.ispartof | PLoS One, 2012, vol. 7, num. 2, p. e32785 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0032785 | - |
dc.rights | cc-by (c) Pasarín, M. et al., 2012 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Malalties del fetge | - |
dc.subject.classification | Endoteli | - |
dc.subject.classification | Fibrosi pulmonar | - |
dc.subject.other | Liver diseases | - |
dc.subject.other | Endothelium | - |
dc.subject.other | Pulmonary fibrosis | - |
dc.title | Sinusoidal Endothelial Dysfunction Precedes Inflammation and Fibrosis in a Model of NAFLD | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 624196 | - |
dc.date.updated | 2013-05-22T08:28:57Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22509248 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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624196.pdf | 511.78 kB | Adobe PDF | View/Open |
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