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http://hdl.handle.net/2445/43778
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DC Field | Value | Language |
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dc.contributor.author | Parvas, Maryam | - |
dc.contributor.author | Bueno i Torrens, David, 1965- | - |
dc.date.accessioned | 2013-05-27T17:43:04Z | - |
dc.date.available | 2013-05-27T17:43:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 2156-8456 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43778 | - |
dc.description.abstract | In vertebrates, early brain development takes place at the expanded anterior end of the neural tube, which is filled with embryonic cerebrospinal fluid (E-CSF). We have recently identified a transient blood-CSF barrier that forms between embryonic days E3 and E4 in chick embryos and that is responsible for the transport of proteins and control of E-CSF homeostasis, including osmolarity. Here we examined the presence of glucose transporter GLUT-1 as well the presence of caveolae-structural protein Caveolin1 (CAV-1) in the embryonic blood-CSF barrier which may be involved in the transport of glucose and of proteins, water and ions respectively across the neuroectoderm. In this paper we demonstrate the presence of GLUT-1 and CAV-1 in endothelial cells of blood vessels as well as in adjacent neuroectodermal cells, located in the embryonic blood-CSF barrier. In blood vessels, these proteins were detected as early as E4 in chick embryos and E12.7 in rat embryos, i.e. the point at which the embryonic blood-CSF barrier acquires this function. In the neuroectoderm of the embryonic blood-CSF barrier, GLUT-1 was also detected at E4 and E12.7 respectively, and CAV-1 was detected shortly thereafter in both experimental models. These experiments contribute to delineating the extent to which the blood-CSF embryonic barrier controls E-CSF composition and homeostasis during early stages of brain development in avians and mammals. Our results suggest the regulation of glucose transport to the E-CSF by means of GLUT-1 and also suggest a mechanism by which proteins are transported via transcellular routes across the neuroectoderm, thus reinforcing the crucial role of E-CSF in brain development. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Scientific Research Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.4236/abb.2010.14041 | - |
dc.relation.ispartof | Advances in Bioscience and Biotechnology , 2010, vol. 1, p. 315-321 | - |
dc.relation.uri | http://dx.doi.org/10.4236/abb.2010.14041 | - |
dc.rights | cc-by (c) Parvas, Maryam et al., 2010 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Cervell | - |
dc.subject.classification | Sistema nerviós central | - |
dc.subject.classification | Neurobiologia del desenvolupament | - |
dc.subject.other | Brain | - |
dc.subject.other | Central nervous system | - |
dc.subject.other | Developmental neurobiology | - |
dc.title | The embryonic blood-CSF barrier has molecular elements for specific glucose transport and for the general transport of molecules via transcellular routes. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 588554 | - |
dc.date.updated | 2013-05-27T17:43:04Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
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