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Title: | APOE status modulates the changes in network connectivity induced by brain stimulation in non-demented elders |
Author: | Peña-Gómez, Cleofé Solé Padullés, Cristina Clemente, Immaculada Junqué i Plaja, Carme, 1955- Bargalló Alabart, Núria Bosch Capdevila, Beatriz Molinuevo, José Luis Valls Solé, Josep Pascual Leone, Álvaro, 1961- Bartrés Faz, David |
Keywords: | Lesions cerebrals Proteïnes Estimulació del cervell Brain damage Proteins Brain stimulation |
Issue Date: | 13-Nov-2012 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | Behavioral consequences of a brain insult represent an interaction between the injury and the capacity of the rest of the brain to adapt to it. We provide experimental support for the notion that genetic factors play a critical role in such adaptation. We induced a controlled brain disruption using repetitive transcranial magnetic stimulation (rTMS) and show that APOE status determines its impact on distributed brain networks as assessed by functional MRI (fMRI).Twenty non-demented elders exhibiting mild memory dysfunction underwent two fMRI studies during face-name encoding tasks (before and after rTMS). Baseline task performance was associated with activation of a network of brain regions in prefrontal, parietal, medial temporal and visual associative areas. APOE ε4 bearers exhibited this pattern in two separate independent components, whereas ε4-non carriers presented a single partially overlapping network. Following rTMS all subjects showed slight ameliorations in memory performance, regardless of APOE status. However, after rTMS APOE ε4-carriers showed significant changes in brain network activation, expressing strikingly similar spatial configuration as the one observed in the non-carrier group prior to stimulation. Similarly, activity in areas of the default-mode network (DMN) was found in a single component among the ε4-non bearers, whereas among carriers it appeared disaggregated in three distinct spatiotemporal components that changed to an integrated single component after rTMS. Our findings demonstrate that genetic background play a fundamental role in the brain responses to focal insults, conditioning expression of distinct brain networks to sustain similar cognitive performance. |
Note: | Correction: https://doi.org/10.1371/annotation/fe36cdbc-5ad0-40d4-8289-fe78d2011ca4 |
Note: | Reproducció del document publicat a: 10.1371/journal.pone.0051833 |
It is part of: | PLoS One, 2012, vol. 7, num. 12, p. e51833 |
URI: | http://hdl.handle.net/2445/43904 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0051833 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Psicologia Clínica i Psicobiologia) |
Files in This Item:
File | Description | Size | Format | |
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617657.pdf | 1.5 MB | Adobe PDF | View/Open | |
640497_Correction.pdf | Correcció | 108.82 kB | Adobe PDF | View/Open |
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