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http://hdl.handle.net/2445/43964
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DC Field | Value | Language |
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dc.contributor.author | Bahima Borràs, Laia | - |
dc.contributor.author | Balana, Bartosz | - |
dc.contributor.author | Bodhinathan, Karthik | - |
dc.contributor.author | Taura, Jaume | - |
dc.contributor.author | Taylor, Natalie M. | - |
dc.contributor.author | Nettleton, Margaret Y. | - |
dc.contributor.author | Ciruela Alférez, Francisco | - |
dc.contributor.author | Slesinger, Paul A. | - |
dc.date.accessioned | 2013-06-02T16:53:20Z | - |
dc.date.available | 2013-06-02T16:53:20Z | - |
dc.date.issued | 2013-02-26 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/43964 | - |
dc.description.abstract | G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putative Ras-association (RA) domain with unknown function. Deleting the RA domain in SNX27b (SNX27b-DRA) prevents the down-regulation of GIRK2c/GIRK3 channels. Similarly, a point mutation (K305A) in the RA domain disrupts regulation of GIRK2c/GIRK3 channels and reduces H-Ras binding in vitro. Finally, the dominant-negative H-Ras (S17N) occludes the SNX27b-dependent decrease in surface expression of GIRK2c/GIRK3 channels. Thus, the presence of a functional RA domain and the interaction with Ras-like G proteins comprise a novel mechanism for modulating SNX27b control of GIRK channel surface expression and cellular excitability. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://doi.org/10.1371/journal.pone.0059800 | - |
dc.relation.ispartof | PLoS One, 2013, vol. 8, num. 3, p. e59800 | - |
dc.relation.uri | http://doi.org/10.1371/journal.pone.0059800 | - |
dc.rights | cc-by (c) Bahima Borràs, Laia et al., 2013 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Patologia i Terapèutica Experimental) | - |
dc.subject.classification | Proteïnes ras | - |
dc.subject.classification | Canals de potassi | - |
dc.subject.classification | Proteïnes G | - |
dc.subject.other | Ras proteins | - |
dc.subject.other | Potassium channels | - |
dc.subject.other | G Proteins | - |
dc.title | Ras-association domain of sorting nexin 27 is critical for regulating expression of GIRK potassium channels | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 624060 | - |
dc.date.updated | 2013-06-02T16:53:20Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 23536889 | - |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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624060.pdf | 4.17 MB | Adobe PDF | View/Open |
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