Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/43987
Title: Differential regulation of RasGAPs in cancer
Author: Grewal, Thomas
Koese, Meryem
Tebar Ramon, Francesc
Enrich Bastús, Carles
Keywords: Proteïnes ras
Carcinogènesi
Ras proteins
Carcinogenesis
Issue Date: 2011
Publisher: Sage Publications
Abstract: Ever since their discovery as cellular counterparts of viral oncogenes more than 25 years ago, much progress has been made in understanding the complex networks of signal transduction pathways activated by oncogenic Ras mutations in human cancers. The activity of Ras is regulated by nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs), and much emphasis has been put into the biochemical and structural analysis of the Ras/GAP complex. The mechanisms by which GAPs catalyze Ras-GTP hydrolysis have been clarified and revealed that oncogenic Ras mutations confer resistance to GAPs and remain constitutively active. However, it is yet unclear how cells coordinate the large and divergent GAP protein family to promote Ras inactivation and ensure a certain biological response. Different domain arrangements in GAPs to create differential protein-protein and protein-lipid interactions are probably key factors determining the inactivation of the 3 Ras isoforms H-, K-, and N-Ras and their effector pathways. In recent years, in vitro as well as cell- and animal-based studies examining GAP activity, localization, interaction partners, and expression profiles have provided further insights into Ras inactivation and revealed characteristics of several GAPs to exert specific and distinct functions. This review aims to summarize knowledge on the cell biology of RasGAP proteins that potentially contributes to differential regulation of spatiotemporal Ras signaling.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1177/1947601911407330
It is part of: Genes & Cancer, 2011, vol. 2, num. 3, p. 288-297
Related resource: http://dx.doi.org/10.1177/1947601911407330
URI: http://hdl.handle.net/2445/43987
ISSN: 1947-6019
Appears in Collections:Articles publicats en revistes (Biomedicina)

Files in This Item:
File Description SizeFormat 
599644.pdf399.49 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.