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http://hdl.handle.net/2445/44003
Title: | Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke |
Author: | Cervera Álvarez, Álvaro Planas Obradors, Anna Maria Justicia Mercader, Carles Urra, Xabier Jensenius, Jens C. Torres Peraza, Jesús Fernando Lozano Soto, Francisco Chamorro Sánchez, Ángel |
Keywords: | Enzims proteolítics Infart cerebral Immunitat Models animals en la investigació Proteolytic enzymes Cerebral infarctio Immunity Animal models in research |
Issue Date: | Feb-2010 |
Publisher: | Public Library of Science (PLoS) |
Abstract: | The complement system is a major effector of innate immunity that has been involved in stroke brain damage. Complement activation occurs through the classical, alternative and lectin pathways. The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans. |
Note: | Reproducció del document publicat a: 10.1371/journal.pone.0008433 |
It is part of: | PLoS One, 2010, vol. 5, num. 2, p. e8433 |
URI: | http://hdl.handle.net/2445/44003 |
Related resource: | http://dx.doi.org/10.1371/journal.pone.0008433 |
ISSN: | 1932-6203 |
Appears in Collections: | Articles publicats en revistes (Biomedicina) |
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