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http://hdl.handle.net/2445/44092
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DC Field | Value | Language |
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dc.contributor.author | Harrison, Ben J. | - |
dc.contributor.author | Pujol Nuez, Jesús | - |
dc.contributor.author | Contreras Rodríguez, Oren | - |
dc.contributor.author | Soriano Mas, Carles | - |
dc.contributor.author | López-Solà, Marina | - |
dc.contributor.author | Deus Yela, Juan | - |
dc.contributor.author | Ortiz, Hector | - |
dc.contributor.author | Blanco Hinojo, Laura, 1981- | - |
dc.contributor.author | Alonso Ortega, María del Pino | - |
dc.contributor.author | Hernández Ribas, Rosa | - |
dc.contributor.author | Cardoner, N. (Narcís) | - |
dc.contributor.author | Menchón Magriñá, José Manuel | - |
dc.date.accessioned | 2013-06-06T14:10:13Z | - |
dc.date.available | 2013-06-06T14:10:13Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/44092 | - |
dc.description.abstract | Activity decreases, or deactivations, of midline and parietal cortical brain regions are routinely observed in human functional neuroimaging studies that compare periods of task-based cognitive performance with passive states, such as rest. It is now widely held that such task-induced deactivations index a highly organized"default-mode network" (DMN): a large-scale brain system whose discovery has had broad implications in the study of human brain function and behavior. In this work, we show that common task-induced deactivations from rest also occur outside of the DMN as a function of increased task demand. Fifty healthy adult subjects performed two distinct functional magnetic resonance imaging tasks that were designed to reliably map deactivations from a resting baseline. As primary findings, increases in task demand consistently modulated the regional anatomy of DMN deactivation. At high levels of task demand, robust deactivation was observed in non-DMN regions, most notably, the posterior insular cortex. Deactivation of this region was directly implicated in a performance-based analysis of experienced task difficulty. Together, these findings suggest that task-induced deactivations from rest are not limited to the DMN and extend to brain regions typically associated with integrative sensory and interoceptive processes. | - |
dc.format.extent | 9 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: 10.1371/journal.pone.0022964 | - |
dc.relation.ispartof | PLoS One, 2011, vol. 6, num. 7, p. e22964 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0022964 | - |
dc.rights | cc-by (c) Harrison, Ben J. et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Cognició | - |
dc.subject.classification | Mapatge del cervell | - |
dc.subject.classification | Assaigs clínics | - |
dc.subject.other | Cognition | - |
dc.subject.other | Brain mapping | - |
dc.subject.other | Clinical trials | - |
dc.title | Task-induced deactivation from rest extends beyond the default mode brain network | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 612670 | - |
dc.date.updated | 2013-06-06T14:10:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 21829564 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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612670.pdf | 418.1 kB | Adobe PDF | View/Open |
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