Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/44093
Title: Reinforcement versus Fluidization in Cytoskeletal Mechanoresponsiveness
Author: Krishnan, Ramaswamy
Park, Chan Young
Lin, Yu-Chun
Mead, Jere
Jaspers, Richard T.
Trepat Guixer, Xavier
Lenormand, Guillaume
Tambe, Dhananjay
Smolensky, Alexander V.
Knoll, Andrew H.
Butler, James P.
Fredberg, Jeffrey J.
Keywords: Citosquelet
Proteïnes citosquelètiques
Regulació cel·lular
Cytoskeleton
Cytoskeletal proteins
Cellular control mechanisms
Issue Date: 2009
Publisher: Public Library of Science (PLoS)
Abstract: Every adherent eukaryotic cell exerts appreciable traction forces upon its substrate. Moreover, every resident cell within the heart, great vessels, bladder, gut or lung routinely experiences large periodic stretches. As an acute response to such stretches the cytoskeleton can stiffen, increase traction forces and reinforce, as reported by some, or can soften and fluidize, as reported more recently by our laboratory, but in any given circumstance it remains unknown which response might prevail or why. Using a novel nanotechnology, we show here that in loading conditions expected in most physiological circumstances the localized reinforcement response fails to scale up to the level of homogeneous cell stretch; fluidization trumps reinforcement. Whereas the reinforcement response is known to be mediated by upstream mechanosensing and downstream signaling, results presented here show the fluidization response to be altogether novel: it is a direct physical effect of mechanical force acting upon a structural lattice that is soft and fragile. Cytoskeletal softness and fragility, we argue, is consistent with early evolutionary adaptations of the eukaryotic cell to material properties of a soft inert microenvironment.
Note: Reproducció del document publicat a: 10.1371/journal.pone.0005486
It is part of: PLoS One, 2009, vol. 4, num. 5, p. e5486
Related resource: http://dx.doi.org/10.1371/journal.pone.0005486
URI: http://hdl.handle.net/2445/44093
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (Ciències Fisiològiques)

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