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Title: Common genetic variation and the control of HIV-1 in humans
Author: Fellay, Jacques
Ge, Dongliang
Shianna, Kevin V.
Colombo, Sara
Ledergerber, Bruno
Cirulli, Elisabeth T.
Urban, Thomas J.
Zhang, Kunlin
Gumbs, Curtis E.
Smith, Jason P.
Castagna, Antonella
Cozzi-Lepri, Alessandro
De Luca, Andrea
Easterbrook, Philippa
Günthard, Huldrych F.
Mallal, Simon
Mussini, Cristina
Dalmau, Judith
Martinez-Picado, Javier
Miró Meda, José M.
Obel, Niels
Wolinsky, Steven
Martinson, Jeremy J
Detels, Roger
Margolick, Joseph B.
Jacobson, Lisa P.
Descombes, Patrick
Antonarakis, Stylianos E.
Beckmann, Jacques
O'Brien, Stephen J.
Letvin, Norman L.
McMichael, Andrew J.
Haynes, Barton F.
Carrington, Mary
Feng, Sheng
Telenti, Amalio
Goldstein, David B.
Keywords: Genètica molecular
VIH (Virus)
Molecular genetics
HIV (Viruses)
Issue Date: 24-Dec-2009
Publisher: Public Library of Science (PLoS)
Abstract: To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic variants explaining down to 1.3% of the variability in viral load at set point. We provide overwhelming confirmation of three associations previously reported in a genome-wide study and show further independent effects of both common and rare variants in the Major Histocompatibility Complex region (MHC). We also examined the polymorphisms reported in previous candidate gene studies and fail to support a role for any variant outside of the MHC or the chemokine receptor cluster on chromosome 3. In addition, we evaluated functional variants, copy-number polymorphisms, epistatic interactions, and biological pathways. This study thus represents a comprehensive assessment of common human genetic variation in HIV-1 control in Caucasians.
Note: Reproducció del document publicat a:
It is part of: PLoS Genetics, 2009, vol. 5, num. 12, p. e1000791.
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ISSN: 1553-7390
Appears in Collections:Articles publicats en revistes (Medicina)

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