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DC Field | Value | Language |
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dc.contributor.author | Miró Meda, José M. | - |
dc.contributor.author | Manzardo, Christian | - |
dc.contributor.author | Mussini, Cristina | - |
dc.contributor.author | Johnson, Margaret M. | - |
dc.contributor.author | D'Arminio Monforte, Antonella | - |
dc.contributor.author | Antinori, Antonella | - |
dc.contributor.author | Gill, M. John | - |
dc.contributor.author | Sighinolfi, Laura | - |
dc.contributor.author | Uberti-Foppa, Caterina | - |
dc.contributor.author | Borghi, Vanni | - |
dc.contributor.author | Sabin, Caroline | - |
dc.contributor.author | Late Presenters Investigators | - |
dc.date.accessioned | 2013-06-13T10:51:27Z | - |
dc.date.available | 2013-06-13T10:51:27Z | - |
dc.date.issued | 2011-10-17 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2445/44223 | - |
dc.description.abstract | Objectives: We analyzed clinical progression among persons diagnosed with HIV at the time of an AIDS-defining event, and assessed the impact on outcome of timing of combined antiretroviral treatment (cART). Methods: Retrospective, European and Canadian multicohort study.. Patients were diagnosed with HIV from 1997-2004 and had clinical AIDS from 30 days before to 14 days after diagnosis. Clinical progression (new AIDS event, death) was described using Kaplan-Meier analysis stratifying by type of AIDS event. Factors associated with progression were identified with multivariable Cox regression. Progression rates were compared between those starting early (< 30 days after AIDS event) or deferred (30-270 days after AIDS event) cART. Results: The median (interquartile range) CD4 count and viral load (VL) at diagnosis of the 584 patients were 42 (16, 119) cells/ mL and 5.2 (4.5, 5.7) log 10 copies/mL. Clinical progression was observed in 165 (28.3%) patients. Older age, a higher VL at diagnosis, and a diagnosis of non-Hodgkin lymphoma (NHL) (vs. other AIDS events) were independently associated with disease progression. Of 366 patients with an opportunistic infection, 178 (48.6%) received early cART. There was no significant difference in clinical progression between those initiating cART early and those deferring treatment (adjusted hazard ratio 1.32 [95% confidence interval 0.87, 2.00], p=0.20). Conclusions: Older patients and patients with high VL or NHL at diagnosis had a worse outcome. Our data suggest that earlier initiation of cART may be beneficial among HIV-infected patients diagnosed with clinical AIDS in our setting. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science (PLoS) | - |
dc.relation.isformatof | Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0026009 | - |
dc.relation.ispartof | PLoS One, 2011, vol. 6, num. 10, p. e26009 | - |
dc.relation.uri | http://dx.doi.org/10.1371/journal.pone.0026009 | - |
dc.rights | cc-by (c) Miro, J.M. et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.classification | Sida | - |
dc.subject.classification | Antiretrovirals | - |
dc.subject.classification | Terapèutica | - |
dc.subject.classification | Persones seropositives | - |
dc.subject.other | HIV (Viruses) | - |
dc.subject.other | AIDS (Disease) | - |
dc.subject.other | Antiretroviral agents | - |
dc.subject.other | Therapeutics | - |
dc.subject.other | HIV-positive persons | - |
dc.title | Survival outcomes and effect of early vs. deferred cART among HIV-infected patients diagnosed at the time of an AIDS-defining event: a cohort analysis. | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 610259 | - |
dc.date.updated | 2013-06-13T10:51:28Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22043301 | - |
Appears in Collections: | Articles publicats en revistes (Medicina) |
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