Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/44244
Title: Solid-phase synthesis and DNA binding studies of dichloroplatinum(II) conjugates of dicarba analogues of octreotide as a new anticancer drugs
Author: Barragán, Flavia
Moreno Martínez, Virtudes
Marchán Sancho, Vicente
Keywords: ADN
Química bioinorgànica
Quimioteràpia del càncer
Cèl·lules canceroses
Toxicitat dels medicaments
DNA
Bioinorganic chemistry
Cancer chemotherapy
Cancer cells
Drug toxicity
Issue Date: 2009
Publisher: Royal Society of Chemistry
Abstract: The first dichloroplatinum(II) conjugates of dicarba analogues of octreotide , which is expected to act as a"tumour-targeting device", have been efficiently synthesized following a stepwise solid-phase approach; these compounds emulate the mechanism of cisplatin since they form a 1,2-intrastrand cross-link with two consecutive guanines of an oligonucleotide.
Note: Versió postprint del document publicat a: http://dx.doi.org/10.1039/B909698A
It is part of: Chemical Communications, 2009, p. 4705-4707
Related resource: http://dx.doi.org/10.1039/B909698A
URI: http://hdl.handle.net/2445/44244
ISSN: 1359-7345
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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